Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHODS FOR THE PREPARATION OF P1 - ALKOXYPHENYL - RIBOFURANOSIDE, P4 -ADENOSINE TETRAPHOSPHATE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2009/102928
Kind Code:
A3
Abstract:
The invention provides compounds and methods for making adenosine-ribofuranoside tetraphosphate compounds. The compounds are contemplated to have activity at the P2Y receptor and may be used in the treatment of medical disorders such as cystic fibrosis and upper respiratory disorders.

Inventors:
BALDINO, Carmen, M. (4 Catarina Lane, Woburn, MA, 01801, US)
COOK, P., Dan (1447 Summit Avenue, #2Cardiff-By-The-Sea, CA, 92007, US)
GHOSH, Shomir (134 Sewall Avenue, Brookline, MA, 02446, US)
VARADY, Lazlo (16 Walnut Hill Road, Newton, MA, 02459, US)
WALDBACH, Thomas, Andreas (Am Kirschberg 11a, Neuengonna, Neuengonna, DE)
WANG, Zhongguo (19 Earl Street, Lexington, MA, 02421, US)
Application Number:
US2009/034018
Publication Date:
July 07, 2011
Filing Date:
February 13, 2009
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
MICRODOSE THERAPEUTX, INC. (4262 US Route 1, Monmouth Junction, NJ, 08852, US)
BALDINO, Carmen, M. (4 Catarina Lane, Woburn, MA, 01801, US)
COOK, P., Dan (1447 Summit Avenue, #2Cardiff-By-The-Sea, CA, 92007, US)
GHOSH, Shomir (134 Sewall Avenue, Brookline, MA, 02446, US)
VARADY, Lazlo (16 Walnut Hill Road, Newton, MA, 02459, US)
WALDBACH, Thomas, Andreas (Am Kirschberg 11a, Neuengonna, Neuengonna, DE)
WANG, Zhongguo (19 Earl Street, Lexington, MA, 02421, US)
International Classes:
C07H15/203; C07H19/20
Domestic Patent References:
WO2008060632A22008-05-22
WO2003011885A12003-02-13
Foreign References:
US20050085439A12005-04-21
Other References:
SHIMAZU M ET AL: "FACILE SYNTHESIS OF NUCLEOTIDES CONTAINING POLYPHOSPHATES BY MANGANESE-II AND CADMIUM-II ION-CATALYZED PYROPHOSPHATE BOND FORMATION IN AQUEOUS SOLUTION", TETRAHEDRON LETTERS, vol. 31, no. 2, 1990, pages 235 - 238, XP002636622, ISSN: 0040-4039
REISS J R ET AL: "Dismutation reactions of nucleoside polyphosphates. 3. The synthesis of alpha, omega-dinucleoside 5'-polyphosphates.", THE JOURNAL OF ORGANIC CHEMISTRY OCT 1965 LNKD- PUBMED:5846146, vol. 30, no. 10, October 1965 (1965-10-01), pages 3381 - 3387, XP002636623, ISSN: 0022-3263
SOOD ANUP ET AL: "Terminal phosphate-labeled nucleotides with improved substrate properties for homogeneous nucleic acid assays.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2 MAR 2005 LNKD- PUBMED:15724985, vol. 127, no. 8, 2 March 2005 (2005-03-02), pages 2394 - 2395, XP002636624, ISSN: 0002-7863
NG K-M E ET AL: "THE ACTION OF A WATER-S0LUBLE CARBODIIMIDE ON ADENOSINE-5'-POLYPHOSPHATES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 15, no. 8, 1 January 1987 (1987-01-01), pages 3573 - 3580, XP002073883, ISSN: 0305-1048
HAN Q ET AL: "One-flask synthesis of dinucleoside tetra- and pentaphosphates", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 10, 1 May 2006 (2006-05-01), pages 2075 - 2077, XP003020699, ISSN: 1523-7060, DOI: DOI:10.1021/OL060491D
NOTTBOHM AMANDA C ET AL: "A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, vol. 46, no. 12, 1 January 2007 (2007-01-01), pages 2066 - 2069, XP002502780, ISSN: 1433-7851, DOI: DOI:10.1002/ANIE.200603988
WOENCKHAUS C ET AL: "[Synthesis and biochemical properties of nicotinamide-phenyl-dinucleo tide].", CHEMISCHE BERICHTE MAY 1966 LNKD- PUBMED:4228732, vol. 99, no. 5, May 1966 (1966-05-01), pages 1712 - 1717, XP002636625, ISSN: 0009-2940
MAZZELLA L J ET AL: "Mechanistic diagnoses of N-ribohydrolases and purine nucleoside phosphorylase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 19960228 US LNKD- DOI:10.1021/JA953537Z, vol. 118, no. 8, 28 February 1996 (1996-02-28), pages 2111 - 2112, XP002636626, ISSN: 0002-7863
Attorney, Agent or Firm:
SOLOWAY, Norman P. et al. (HAYES SOLOWAY P.C, 3450 E. Sunrise Drive Suite 14, Tucson Arizona, 85718, US)
Download PDF: