Title:
METHODS FOR PREPARING BILE ACIDS
Document Type and Number:
WIPO Patent Application WO/2019/024920
Kind Code:
A1
Abstract:
The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.
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Inventors:
LIU DEJUN (CN)
QIAN YINGZHE (CN)
LEE JUNHO (KR)
SONG YOONSEOK (KR)
QIAN YINGZHE (CN)
LEE JUNHO (KR)
SONG YOONSEOK (KR)
Application Number:
PCT/CN2018/098535
Publication Date:
February 07, 2019
Filing Date:
August 03, 2018
Export Citation:
Assignee:
MEDYTOX INC (KR)
LIU DEJUN (CN)
QIAN YINGZHE (CN)
LIU DEJUN (CN)
QIAN YINGZHE (CN)
International Classes:
C07J9/00; A61K31/56; A61P31/04; C07J1/00; C07J13/00; C07J75/00
Domestic Patent References:
| WO2012047495A2 | 2012-04-12 |
Foreign References:
| CN1308085A | 2001-08-15 | |||
| CN101711254A | 2010-05-19 |
Other References:
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DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 88378-76-1
DATABASE REG 12 May 2002 (2002-05-12), retrieved from STN Database accession no. 413597-22-5
DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 80322-20-9
DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 26425-68-3
DATABASE REGISTRY 31 December 2010 (2010-12-31), retrieved from STN Database accession no. RN 1258252-84-4
DENG, LEHUA ET AL.: "Synthesis of 5, 6-Dihydro-OSW-1 and Its Antitumor Activities", CHINESE JOURNAL OF CHEMISTRY, vol. 22, no. 9, 31 December 2004 (2004-12-31), pages 994 - 998, XP055571604
See also references of EP 3645548A4
DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 88378-76-1
DATABASE REG 12 May 2002 (2002-05-12), retrieved from STN Database accession no. 413597-22-5
DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 80322-20-9
DATABASE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. RN 26425-68-3
DATABASE REGISTRY 31 December 2010 (2010-12-31), retrieved from STN Database accession no. RN 1258252-84-4
DENG, LEHUA ET AL.: "Synthesis of 5, 6-Dihydro-OSW-1 and Its Antitumor Activities", CHINESE JOURNAL OF CHEMISTRY, vol. 22, no. 9, 31 December 2004 (2004-12-31), pages 994 - 998, XP055571604
See also references of EP 3645548A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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