Title:
METHODS FOR PREPARING INDAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2006048761
Kind Code:
A3
Abstract:
The invention relates to methods for preparing compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) are useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.
Inventors:
BABU SRINIVASAN (US)
DAGNINO RAYMOND JR (US)
HADDACH AUBREY (US)
MITCHELL MARK BRYAN (US)
OUELLETTE MICHAEL ALLEN (US)
SAENZ JAMES EDWARD (US)
SRIRANGAM JAYARAM KATSURI (US)
YU SHU (US)
ZOOK SCOTT EDWARD (US)
DAGNINO RAYMOND JR (US)
HADDACH AUBREY (US)
MITCHELL MARK BRYAN (US)
OUELLETTE MICHAEL ALLEN (US)
SAENZ JAMES EDWARD (US)
SRIRANGAM JAYARAM KATSURI (US)
YU SHU (US)
ZOOK SCOTT EDWARD (US)
Application Number:
PCT/IB2005/003348
Publication Date:
June 22, 2006
Filing Date:
October 21, 2005
Export Citation:
Assignee:
PFIZER (US)
BABU SRINIVASAN (US)
DAGNINO RAYMOND JR (US)
HADDACH AUBREY (US)
MITCHELL MARK BRYAN (US)
OUELLETTE MICHAEL ALLEN (US)
SAENZ JAMES EDWARD (US)
SRIRANGAM JAYARAM KATSURI (US)
YU SHU (US)
ZOOK SCOTT EDWARD (US)
BABU SRINIVASAN (US)
DAGNINO RAYMOND JR (US)
HADDACH AUBREY (US)
MITCHELL MARK BRYAN (US)
OUELLETTE MICHAEL ALLEN (US)
SAENZ JAMES EDWARD (US)
SRIRANGAM JAYARAM KATSURI (US)
YU SHU (US)
ZOOK SCOTT EDWARD (US)
International Classes:
C07D231/14; C07D231/56; C07D401/14; C07D405/14
Domestic Patent References:
| WO2001002369A2 | 2001-01-11 |
Foreign References:
| DE2136284A1 | 1972-08-31 |
Other References:
HINKEL L E ET AL: "DICHLORO-O-XYLENES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1934, pages 1946 - 1948, XP008058037, ISSN: 0368-1769
CHANG KIU LEE, JI SOOK YU, YOUNG RAN LI: "Determination of Aromaticity Indices of Thiophene and Furan by Nuclear Magnetic Resonance Spectroscopic Analysis of Their Anilides", J. HETEROCYCLIC CHEM., vol. 39, 2002, pages 1219 - 1227, XP002375492
HUTCHINSON ET AL: "Antitumor Benzothiazoles. 14. Synthesis and in Vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 2001, pages 1446 - 1455, XP002215317, ISSN: 0022-2623
KOHICHIRO YOSHINO, NORIYUKI HORI, MANABU HORI: "Organic Phosphorus Compounds. Part 3 [1]. Synthesis of 5-Fluorosubstituted Benzothiazolylbenzylphosphonates", J. HETEROCYCLIC CHEM., vol. 26, 1989, pages 1039 - 1043, XP002375493
CHATTAWAY F D ET AL: "DERIVATIVES OF 3:5-DIHALOGEN-SUBSTITUTED ANILINES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1935, pages 1005 - 1008, XP008058035, ISSN: 0368-1769
D. E. PEARSON, H. W. POPE, W. W. HARGROVE, W. E. STAMPER: "The Swamping Catalyst Effect. II. Nuclear Halogenation of Aromatic Aldehydes and Ketones", J. ORG. CHEM., vol. 23, 1958, pages 1412 - 1416, XP002375494
LAEV S S ET AL: "A new approach to polyfluoroaromatic amines with an unsubstituted position ortho to the amino group", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 110, no. 1, 25 July 2001 (2001-07-25), pages 43 - 46, XP004255410, ISSN: 0022-1139
PERRY R J ET AL: "2-Arylbenzoxazole Formation Through ortho-Fluoro Displacement Reactions", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 57, no. 23, 6 November 1992 (1992-11-06), pages 6351 - 6354, XP001005503, ISSN: 0022-3263
CHANG KIU LEE, JI SOOK YU, YOUNG RAN LI: "Determination of Aromaticity Indices of Thiophene and Furan by Nuclear Magnetic Resonance Spectroscopic Analysis of Their Anilides", J. HETEROCYCLIC CHEM., vol. 39, 2002, pages 1219 - 1227, XP002375492
HUTCHINSON ET AL: "Antitumor Benzothiazoles. 14. Synthesis and in Vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 2001, pages 1446 - 1455, XP002215317, ISSN: 0022-2623
KOHICHIRO YOSHINO, NORIYUKI HORI, MANABU HORI: "Organic Phosphorus Compounds. Part 3 [1]. Synthesis of 5-Fluorosubstituted Benzothiazolylbenzylphosphonates", J. HETEROCYCLIC CHEM., vol. 26, 1989, pages 1039 - 1043, XP002375493
CHATTAWAY F D ET AL: "DERIVATIVES OF 3:5-DIHALOGEN-SUBSTITUTED ANILINES", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY. LETCHWORTH, GB, 1935, pages 1005 - 1008, XP008058035, ISSN: 0368-1769
D. E. PEARSON, H. W. POPE, W. W. HARGROVE, W. E. STAMPER: "The Swamping Catalyst Effect. II. Nuclear Halogenation of Aromatic Aldehydes and Ketones", J. ORG. CHEM., vol. 23, 1958, pages 1412 - 1416, XP002375494
LAEV S S ET AL: "A new approach to polyfluoroaromatic amines with an unsubstituted position ortho to the amino group", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 110, no. 1, 25 July 2001 (2001-07-25), pages 43 - 46, XP004255410, ISSN: 0022-1139
PERRY R J ET AL: "2-Arylbenzoxazole Formation Through ortho-Fluoro Displacement Reactions", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 57, no. 23, 6 November 1992 (1992-11-06), pages 6351 - 6354, XP001005503, ISSN: 0022-3263
Download PDF: