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Title:
METHODS FOR PREVENTING GRAFT ISCHEMIA REPERFUSION INJURY DURING EX VIVO MACHINE PERFUSION PRESERVATION
Document Type and Number:
WIPO Patent Application WO/2019/140176
Kind Code:
A1
Abstract:
The invention provides methods for treating ischemia (such as ischemia repertusion injury (IRI)) in tissue (such as transplant donor tissue), comprising contacting the tissue during ex vivo perfusion with a therapeutically effective amount of RNAi (such as siRNA) that specifically hinds to at least a portion of a gene (such as p53) that mediates ischemic injury in the tissue. The invention's methods additionally decrease the risk of tissue rejection and/or or induce immunological tolerance to transplanted tissue.

Inventors:
MARTINS, Paulo (266 South Quinsigamond Ave, Shrewsbury, MA, 01545, US)
E, Xiaofei (15 Powder Hill Way, Westborough, MA, 01581, US)
KOWALIK, Timothy (190 Thompson Road, Princeton, MA, 01541, US)
Application Number:
US2019/013174
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
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Assignee:
UNIVERSITY OF MASSACHUSETTS (One Beacon Street, 31st FloorBoston, MA, 02108, US)
International Classes:
A61K31/713; C12N15/113
Foreign References:
US20160024507A12016-01-28
US20160263195A12016-09-15
US20140030231A12014-01-30
US20050119212A12005-06-02
US20150230453A12015-08-20
US20080311552A12008-12-18
US20140256792A12014-09-11
Attorney, Agent or Firm:
CARROLL, Peter, G. et al. (Medlen & Carroll, LLP1440 Broadway, Suite 101, Oakland CA, 94612, US)
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