Title:
METHODS FOR PREVENTING GRAFT ISCHEMIA REPERFUSION INJURY DURING EX VIVO MACHINE PERFUSION PRESERVATION
Document Type and Number:
WIPO Patent Application WO/2019/140176
Kind Code:
A1
Abstract:
The invention provides methods for treating ischemia (such as ischemia repertusion injury (IRI)) in tissue (such as transplant donor tissue), comprising contacting the tissue during ex vivo perfusion with a therapeutically effective amount of RNAi (such as siRNA) that specifically hinds to at least a portion of a gene (such as p53) that mediates ischemic injury in the tissue. The invention's methods additionally decrease the risk of tissue rejection and/or or induce immunological tolerance to transplanted tissue.
Inventors:
MARTINS, Paulo (266 South Quinsigamond Ave, Shrewsbury, MA, 01545, US)
E, Xiaofei (15 Powder Hill Way, Westborough, MA, 01581, US)
KOWALIK, Timothy (190 Thompson Road, Princeton, MA, 01541, US)
E, Xiaofei (15 Powder Hill Way, Westborough, MA, 01581, US)
KOWALIK, Timothy (190 Thompson Road, Princeton, MA, 01541, US)
Application Number:
US2019/013174
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
UNIVERSITY OF MASSACHUSETTS (One Beacon Street, 31st FloorBoston, MA, 02108, US)
International Classes:
A61K31/713; C12N15/113
Foreign References:
| US20160024507A1 | 2016-01-28 | |||
| US20160263195A1 | 2016-09-15 | |||
| US20140030231A1 | 2014-01-30 | |||
| US20050119212A1 | 2005-06-02 | |||
| US20150230453A1 | 2015-08-20 | |||
| US20080311552A1 | 2008-12-18 | |||
| US20140256792A1 | 2014-09-11 |
Attorney, Agent or Firm:
CARROLL, Peter, G. et al. (Medlen & Carroll, LLP1440 Broadway, Suite 101, Oakland CA, 94612, US)
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