Title:
METHODS FOR PREVENTING GRAFT ISCHEMIA REPERFUSION INJURY DURING EX VIVO MACHINE PERFUSION PRESERVATION
Document Type and Number:
WIPO Patent Application WO/2019/140176
Kind Code:
A1
Abstract:
The invention provides methods for treating ischemia (such as ischemia repertusion injury (IRI)) in tissue (such as transplant donor tissue), comprising contacting the tissue during ex vivo perfusion with a therapeutically effective amount of RNAi (such as siRNA) that specifically hinds to at least a portion of a gene (such as p53) that mediates ischemic injury in the tissue. The invention's methods additionally decrease the risk of tissue rejection and/or or induce immunological tolerance to transplanted tissue.
Inventors:
MARTINS PAULO (US)
E XIAOFEI (US)
KOWALIK TIMOTHY (US)
E XIAOFEI (US)
KOWALIK TIMOTHY (US)
Application Number:
US2019/013174
Publication Date:
July 18, 2019
Filing Date:
January 11, 2019
Export Citation:
Assignee:
UNIV MASSACHUSETTS (US)
International Classes:
A61K31/713; C12N15/113
Foreign References:
| US20160024507A1 | 2016-01-28 | |||
| US20160263195A1 | 2016-09-15 | |||
| US20140030231A1 | 2014-01-30 | |||
| US20050119212A1 | 2005-06-02 | |||
| US20150230453A1 | 2015-08-20 | |||
| US20080311552A1 | 2008-12-18 | |||
| US20140256792A1 | 2014-09-11 |
Attorney, Agent or Firm:
CARROLL, Peter, G. et al. (LLP1440 Broadway, Suite 101, Oakland CA, US)
Download PDF:
Previous Patent: COMPRESSED AIR DRIVEN MOTOR
Next Patent: VACUUM SEALED LID INSERT FOR INSULATED CONTAINER
Next Patent: VACUUM SEALED LID INSERT FOR INSULATED CONTAINER