Title:
METHODS OF PREVENTING VENTILATOR ASSOCIATED PNEUMONIA BY ORAL ADMINISTRATION OF ANTIMICROBIAL IB-367 PEPTIDES
Document Type and Number:
WIPO Patent Application WO2002064089
Kind Code:
A3
Abstract:
The present invention provides methods of preventing respiratory infections associated with intubation and/or mechanical ventilation-associated pneumonia, in intubated patients. The method generally involves topical administration of a composition comprising an IB-367 peptide to the oral cavity of an intubated patient. As IB-367 peptides engender very little resistance, a signifiant advantage of the invention is that the prophylactic therapy may be applied without having to worry about creating resistant strains of pathogens.
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Inventors:
REDMAN REBECCA
FUCHS HENRY
FUCHS HENRY
Application Number:
PCT/US2002/004362
Publication Date:
December 12, 2002
Filing Date:
February 12, 2002
Export Citation:
Assignee:
INTRABIOTICS PHARMACEUTICALS (US)
International Classes:
A61K9/08; A61K38/00; A61K38/10; A61K47/10; A61K47/12; A61K47/36; A61K47/38; A61M16/04; A61P11/00; A61P11/12; A61P31/04; (IPC1-7): A61K39/00
Domestic Patent References:
| WO2000015207A2 | 2000-03-23 |
Foreign References:
| US5210083A | 1993-05-11 |
Other References:
VESOLE ET AL.: "IB-367 reduces the number of days of severe oral mucositis complicating myeloblative chemotherapy", BLOOD, vol. 94, no. 10, SUPPL. 1, PART 1, 15 November 1999 (1999-11-15), pages 154A, ABSTRACT NO. 675, XP002953765
HANCOCK ET AL.: "Cationic antimicrobial peptide antibiotics", CURRENT OPINION IN ANTI-INFECTIVE INVESTIGATIONAL DRUGS, vol. 2, no. 2, 2000, pages 140 - 144, XP002953766
HANCOCK ET AL.: "Cationic antimicrobial peptide antibiotics", CURRENT OPINION IN ANTI-INFECTIVE INVESTIGATIONAL DRUGS, vol. 2, no. 2, 2000, pages 140 - 144, XP002953766
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