METHODS FOR PRODUCING 5'-NUCLEIC ACID-PROTEIN CONJUGATES

Title:

METHODS FOR PRODUCING 5'-NUCLEIC ACID-PROTEIN CONJUGATES

Document Type and Number:

WIPO Patent Application WO2000072869

Kind Code:

A9

Abstract:

Disclosed herein is a method for generating a 5'-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5'end; (b) providing a non-derivatized protein; and (c) contacting the nucleic acid and the protein under conditions which allow the reactive group to react with the N-terminus of the protein, thereby forming a 5'-nucleic acid-protein conjugate. Also disclosed herein are 5'-nucleic acid-protein conjugates and methods for their use.

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Inventors:

LOHSE PETER
WRIGHT MARTIN C
MCPHERSON MICHAEL

Application Number:

PCT/US2000/015077

Publication Date:

January 31, 2002

Filing Date:

June 01, 2000

Export Citation:

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Assignee:

PHYLOS INC (US)

International Classes:

C07K1/107; C07K1/22; G01N33/566; C07K14/00; C07K17/00; C12N15/00; C12N15/09; G01N37/00; A61K38/00; (IPC1-7): A61K38/16; A61K38/03; C07K14/00

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