Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHODS FOR PRODUCING 6-CARBON MONOMERS
Document Type and Number:
WIPO Patent Application WO/2016/175901
Kind Code:
A3
Abstract:
This document describes materials and methods for, for example, producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.

Inventors:
BOTES, Adriana Leonora (Red House Farm, Daleside Road, Rosedale East Cleveland Y018 8RL, 8RL, GB)
CONRADIE, Alex Van Eck (4 Aberdovey Drive, Eaglescliffe Cleveland TS16 9EZ, 9EZ, GB)
Application Number:
US2015/067099
Publication Date:
December 08, 2016
Filing Date:
December 21, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
INVISTA NORTH AMERICA S.Á.R.L. (Three Little Falls Centre, 2801 Centerville RoadWilmington, Delaware, 19808, US)
INVISTA TECHNOLOGIES S.A.R.L. (Zweigniederlassung St. Gallen, Flurhofstrasse 160, 9000 St. Gallen, Gallen, CH)
International Classes:
C12P7/26; C07H19/207; C12P7/42; C12P7/62
Domestic Patent References:
WO2014047407A12014-03-27
Other References:
MAKOTO HASHIMOTO ET AL: "Aspergillus oryzae CsyB catalyzes the condensation of two beta-ketoacyl-CoAs to form 3-acetyl-4-hydroxy-6-alkyl-alpha-pyrone", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, July 2014 (2014-07-01), pages 19976 - 19984, XP002762734
EUN-JUNG KIM ET AL: "Cloning, expression, purification, crystallization and X-ray crystallographic analysis of beta-ketothiolase B from Ralstonia eutropha H16", ACTA CRYSTALLOGRAPHICA SECTION F, vol. F70, March 2014 (2014-03-01), pages 316 - 319, XP002762735
HASAN DIBA ET AL: "Polyhydroxyalkanoates (PHAs), intracellular pathways and properties", CURRENT WORLD ENVIRONMENT, vol. 10(Special issue 1), May 2015 (2015-05-01), pages 644 - 649, XP002762609
SHUNSUKE SATO ET AL: "Regulation of 3-hydroxyhexanoate composition in PHBH synthesized by recombinant Cupriavidus necator H16 from plant oil by using butyrate as a co-substrate", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 120, 21 March 2015 (2015-03-21), pages 246 - 251, XP055242328
CHRISTOPHER D. FAGE ET AL: "Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous beta-ketoacyl thiolase from Ralstonia eutropha", JOURNAL OF MOLECULAR CATALYSIS B : ENZYMATIC, vol. 121, 17 August 2015 (2015-08-17), pages 113 - 121, XP002755926
Attorney, Agent or Firm:
MOUTA, Carla et al. (Finnegan, Henderson Farabow, Garrett & Dunner, LLP,901 New York Avenue, N, Washington DC, 20001-4413, US)
Download PDF: