Title:
METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2014/105788
Kind Code:
A3
Abstract:
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
Inventors:
BOTES ADRIANA LEONORA (GB)
CONRADIE ALEX VAN ECK (GB)
CHEN CHANGLIN (GB)
PEARLMAN PAUL S (US)
CONRADIE ALEX VAN ECK (GB)
CHEN CHANGLIN (GB)
PEARLMAN PAUL S (US)
Application Number:
PCT/US2013/077411
Publication Date:
November 06, 2014
Filing Date:
December 23, 2013
Export Citation:
Assignee:
INVISTA NORTH AMERICA SARL (US)
International Classes:
C12P7/18; C12N15/63; C12P7/42; C12P7/44; C12P13/00
Domestic Patent References:
| WO2013096898A2 | 2013-06-27 | |||
| WO2013003744A2 | 2013-01-03 | |||
| WO2010068944A2 | 2010-06-17 |
Other References:
MOSTAFA S ELSHAHED ET AL: "Metabolism of Benzoate, Cyclohex-1-ene Carboxylate, and Cyclohexane Carboxylate by Syntrophus aciditrophicus Strain SB in Syntrophic Association with H2-Using Microorganisms", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 67, no. 4, 1 April 2001 (2001-04-01), pages 1728 - 1738, XP008148765, ISSN: 0099-2240, DOI: 10.1128/AEM.67.4.1728-1738.2001
H. MOUTTAKI ET AL: "Cyclohexane Carboxylate and Benzoate Formation from Crotonate in Syntrophus aciditrophicus", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 3, 1 February 2007 (2007-02-01), pages 930 - 938, XP055126451, ISSN: 0099-2240, DOI: 10.1128/AEM.02227-06
MOSTAFA S. ELSHAHED ET AL.: "Benzoate Fermentation by the Anaerobic Bacterium Syntrophus aciditrophicus in the Absence of Hydrogen-Using Microorganisms", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 67, no. 12, 2001, pages 5520 - 5525, XP002726566
H. MOUTTAKI ET AL: "Cyclohexane Carboxylate and Benzoate Formation from Crotonate in Syntrophus aciditrophicus", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 3, 1 February 2007 (2007-02-01), pages 930 - 938, XP055126451, ISSN: 0099-2240, DOI: 10.1128/AEM.02227-06
MOSTAFA S. ELSHAHED ET AL.: "Benzoate Fermentation by the Anaerobic Bacterium Syntrophus aciditrophicus in the Absence of Hydrogen-Using Microorganisms", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 67, no. 12, 2001, pages 5520 - 5525, XP002726566
Attorney, Agent or Firm:
MCCORMICK GRAHAM, Monica et al. (P.O. Box 1022Minneapolis, Minnesota, US)
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