METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS

Title:

METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CARBON CHAIN ELONGATION ASSOCIATED WITH CYCLOHEXANE CARBOXYLATE SYNTHESIS

Document Type and Number:

WIPO Patent Application WO/2014/105788

Kind Code:

A8

Abstract:

This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.

Inventors:

BOTES ADRIANA LEONORA (GB)
CONRADIE ALEX VAN ECK (GB)
CHEN CHANGLIN (GB)
PEARLMAN PAUL S (US)

Application Number:

PCT/US2013/077411

Publication Date:

May 28, 2015

Filing Date:

December 23, 2013

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Assignee:

INVISTA TECH SARL (CH)

International Classes:

C12P7/18; C12N15/63; C12P7/42; C12P7/44; C12P13/00

Attorney, Agent or Firm:

MCCORMICK GRAHAM, Monica et al. (P.O. Box 1022Minneapolis, Minnesota, US)

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