Title:
METHODS OF PRODUCING 7-CARBON CHEMICALS VIA PYRUVATE AND SUCCINATE SEMIALDEHYDE ALDOL CONDENSATION
Document Type and Number:
WIPO Patent Application WO/2014/105797
Kind Code:
A3
Abstract:
This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
Inventors:
BOTES ADRIANA LEONORA (GB)
CONRADIE ALEX VAN ECK (GB)
CHEN CHANGLIN (GB)
PEARLMAN PAUL S (US)
CONRADIE ALEX VAN ECK (GB)
CHEN CHANGLIN (GB)
PEARLMAN PAUL S (US)
Application Number:
PCT/US2013/077430
Publication Date:
December 31, 2014
Filing Date:
December 23, 2013
Export Citation:
Assignee:
INVISTA NORTH AMERICA SARL (US)
International Classes:
C12P7/18; C12P7/42; C12P7/44; C12P13/00
Domestic Patent References:
WO2010068944A2 | 2010-06-17 | |||
WO2013096898A2 | 2013-06-27 | |||
WO2013003744A2 | 2013-01-03 | |||
WO2014105788A2 | 2014-07-03 |
Other References:
DATABASE WPI Week 201304, Derwent World Patents Index; AN 2012-R78158, XP002728487
IZUMI ET AL: "Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 370, no. 5, 14 June 2007 (2007-06-14), pages 899 - 911, XP022117287, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2007.05.006
REA ET AL: "Structure and Mechanism of HpcH: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 373, no. 4, 3 October 2007 (2007-10-03), pages 866 - 876, XP022285563, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2007.06.048
IZUMI ET AL: "Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 370, no. 5, 14 June 2007 (2007-06-14), pages 899 - 911, XP022117287, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2007.05.006
REA ET AL: "Structure and Mechanism of HpcH: A Metal Ion Dependent Class II Aldolase from the Homoprotocatechuate Degradation Pathway of Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 373, no. 4, 3 October 2007 (2007-10-03), pages 866 - 876, XP022285563, ISSN: 0022-2836, DOI: 10.1016/J.JMB.2007.06.048
Attorney, Agent or Firm:
MCCORMICK GRAHAM, Monica et al. (P.O. Box 1022Minneapolis, Minnesota, US)
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