Title:
METHODS OF PRODUCING PLASMA OR SERUM AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/201283
Kind Code:
A3
Abstract:
A method of producing serum or plasma ophthalmic solution ("eye drops") comprises the steps of drawing a blood sample from a subject; adding erythrocyte sedimentation-accelerating agent(s) and an anticoagulant to the blood sample; placing the mixture in a vessel with an inclined well and allowing the phase separation of the solution into an erythrocyte phase and a plasma or serum phase, producing an erythrocyte-depleted serum or plasma; and collecting the erythrocyte-depleted serum or plasma. A method of lubricating the eye of a subject comprises the steps of drawing a blood sample from a subject; adding erythrocyte sedimentation-accelerating agent(s) and an anticoagulant to the blood sample; placing the mixture in a vessel with an inclined well and allowing the phase separation of the solution into an erythrocyte phase and a plasma or serum phase, producing an erythrocyte-depleted serum or plasma; collecting the erythrocyte-depleted serum or plasma; treating the plasma with a platelet activating substance or agent; and applying the erythrocyte-depleted serum or plasma to the eye of the subject. A kit provides components, diagrams, compositions and instructions for performing the methods.
Inventors:
KARLIN JUSTIN (US)
Application Number:
PCT/US2023/065701
Publication Date:
November 30, 2023
Filing Date:
April 13, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
KARLIN JUSTIN (US)
KARLIN JUSTIN (US)
International Classes:
A61F9/007; A61P27/02; A61K35/14; A61K38/16
Domestic Patent References:
| WO2014269931A1 | ||||
| WO2020097528A1 | 2020-05-14 |
Foreign References:
| US9517255B2 | 2016-12-13 | |||
| US20060281739A1 | 2006-12-14 | |||
| US20150125436A1 | 2015-05-07 | |||
| US20210340516A1 | 2021-11-04 |
Attorney, Agent or Firm:
BURKHARDT, Russell, N. et al. (US)
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