Title:
METHODS FOR PRODUCING TRYPTAMINE DERIVATIVES.
Document Type and Number:
WIPO Patent Application WO/2022/248635
Kind Code:
A3
Abstract:
The present disclosure relate to a method for producing a tryptamine derivative of formula (I), wherein the tryptamine derivative (I) is not tryptophane, 4-hydroxytryptamine, N-acetyl-4-hydroxytryptamine, norbaeocystin, baeocystin; psilocybin, psilocin, aeruginascin, halogenated tryptophan, halogenated tryptamine, halogenated N-methylated tryptamine, halogenated N,N-dimethyltryptamine or halogenated Ν,Ν,Ν-trimethyltryptamine; said method comprising providing an indole acceptor of the formula (II), wherein the tryptamine derivative (I) is not tryptophane, 4-hydroxytryptamine, N-acetyl-4-hydroxytryptamine, norbaeocystin, baeocystin; psilocybin, psilocin, aeruginascin, halogenated tryptophan, halogenated tryptamine, halogenated N-methylated tryptamine, halogenated N,N- dimethyltryptamine or halogenated Ν,Ν,Ν-trimethyltryptamine; said method comprising providing an indole acceptor of the formula (II), wherein one or more of Rll, RIV, RV, RVI or RVII is not H and Rill is H or CH2CH2NH2 or CH2CHCOOHNH2; and contacting the indole acceptor with a substituent donor in the precense of one or more enzymes substituting one or more H, OH and/or COOH in the indole acceptor with one or more substituents of the substituent donor.
Inventors:
MILNE NICHOLAS STUART WILLIAM (DK)
NIELSEN ANNETTE MUNCH (DK)
BADEN CAMILLA (DK)
GALLAGE NETHAJI JANESHAWARI (DK)
NIELSEN ANNETTE MUNCH (DK)
BADEN CAMILLA (DK)
GALLAGE NETHAJI JANESHAWARI (DK)
Application Number:
PCT/EP2022/064352
Publication Date:
March 09, 2023
Filing Date:
May 25, 2022
Export Citation:
Assignee:
OCTARINE BIO APS (DK)
International Classes:
C12P17/10; A61K31/4045; C12N9/10; C12N15/52; C12P13/22
Domestic Patent References:
| WO2019173797A1 | 2019-09-12 | |||
| WO2022170438A1 | 2022-08-18 |
Other References:
BLEI, F. ET AL.: "Biocatalytic Production of Psilocybin and Derivatives in Tryptophan Synthase-Enhanced Reactions", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 40, 19 June 2018 (2018-06-19), pages 10028 - 10031, XP071846906, DOI: 10.1002/CHEM.201801047
MANEVSKI, N. ET AL.: "Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases", DRUG METABOLISM AND DISPOSITION, vol. 38, no. 3, 10 November 2009 (2009-11-10), pages 386 - 395, XP055909273, Retrieved from the Internet DOI: 10.1124/dmd.109.031138
SERVILLO, L. ET AL.: "Serotonin 5-O-beta-Glucoside and Its N-Methylated Forms in Citrus Genus Plants", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 63, no. 16, 20 April 2015 (2015-04-20), pages 4220 - 4227, XP093003156, DOI: 10.1021/acs.jafc.5b01031
MANEVSKI, N. ET AL.: "Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases", DRUG METABOLISM AND DISPOSITION, vol. 38, no. 3, 10 November 2009 (2009-11-10), pages 386 - 395, XP055909273, Retrieved from the Internet
SERVILLO, L. ET AL.: "Serotonin 5-O-beta-Glucoside and Its N-Methylated Forms in Citrus Genus Plants", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 63, no. 16, 20 April 2015 (2015-04-20), pages 4220 - 4227, XP093003156, DOI: 10.1021/acs.jafc.5b01031
Attorney, Agent or Firm:
BIRKELAND, Morten (DK)
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