Title:
METHODS OF PROMOTING CELL VIABILITY
Document Type and Number:
WIPO Patent Application WO2004096123
Kind Code:
A3
Abstract:
Methods for promoting viability of a transplant cell population by administering a hydrophilic bile acid, such as ursodeoxycholic acid (UDCA), salts thereof, and analogs thereof (e.g., glycoursodeoxycholic acid and tauroursodeoxycholic acid).
Inventors:
STEER CLIFFORD J (US)
LOW WALTER C (US)
LOW WALTER C (US)
Application Number:
PCT/US2003/009819
Publication Date:
April 14, 2005
Filing Date:
April 02, 2003
Export Citation:
Assignee:
UNIV MINNESOTA (US)
STEER CLIFFORD J (US)
LOW WALTER C (US)
STEER CLIFFORD J (US)
LOW WALTER C (US)
International Classes:
A01N1/00; A01N1/02; C12N5/0793; A61K35/12; A61K; (IPC1-7): A01N1/00; A01N1/02; C12N5/06; C12N5/08
Other References:
FALASCA ET AL.: "Protective role of tauroursoeoxycholate during harvesting and cold storage of human liver", TRANSPLANTATION, vol. 71, no. 9, 15 May 2001 (2001-05-15), pages 1268 - 1276, XP008044995
RODRIGUES ET AL.: "Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 6, 2000, pages 2368 - 2379, XP002985514
FRIMAN ET AL.: "Ursodeoxycholic acid reduces acute rejection in heart allografts rats", TRANSPLANTATION PROCEEDINGS, vol. 24, no. 1, February 1992 (1992-02-01), pages 344 - 345, XP008044996
RODRIGUES ET AL.: "Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 6, 2000, pages 2368 - 2379, XP002985514
FRIMAN ET AL.: "Ursodeoxycholic acid reduces acute rejection in heart allografts rats", TRANSPLANTATION PROCEEDINGS, vol. 24, no. 1, February 1992 (1992-02-01), pages 344 - 345, XP008044996
Download PDF:
Previous Patent: USE OF NGF ANTAGONISTS AND OPIOIDS FOR TREATING PAIN
Next Patent: COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
Next Patent: COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR