Title:
METHODS FOR PURIFICATION OF ARYLSULFATASE A
Document Type and Number:
WIPO Patent Application WO/2013/009686
Kind Code:
A3
Abstract:
Methods of producing arylsulfatase A are described herein. The methods can include one or more steps of chromatography. Exemplary chromatographic steps include ion exchange chromatography, mixed mode chromatography, and hydrophobic interaction chromatography. Compositions containing and methods using arylsulfatase A produced by the methods described herein are also disclosed.
Inventors:
YANG YING (US)
WANG YONG (US)
WANG YONG (US)
Application Number:
PCT/US2012/045927
Publication Date:
February 28, 2013
Filing Date:
July 09, 2012
Export Citation:
Assignee:
SHIRE HUMAN GENETIC THERAPIES (US)
YANG YING (US)
WANG YONG (US)
YANG YING (US)
WANG YONG (US)
International Classes:
C12N9/16
Domestic Patent References:
| WO2005073367A1 | 2005-08-11 | |||
| WO2002098455A2 | 2002-12-12 |
Other References:
GRZEGORZ HESS: "Isolation and comparison of arylsulfatase A from rat liver and Morris hepatoma 7777", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 135, no. 3, 1 October 1983 (1983-10-01), pages 505 - 509, XP055039351, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1983.tb07680.x
FAROOQUI A A ET AL: "ISOLATION CHARACTERIZATION AND THE ROLE OF RABBIT TESTICULAR ARYL SULFATASE A EC-3.1.6.1 IN FERTILIZATION", BIOCHEMICAL JOURNAL, vol. 181, no. 2, 1979, pages 331 - 338, XP002684195, ISSN: 0264-6021
FAROOQUI A A ET AL: "ISOLATION CHARACTERIZATION AND THE ROLE OF RABBIT TESTICULAR ARYL SULFATASE A EC-3.1.6.1 IN FERTILIZATION", BIOCHEMICAL JOURNAL, vol. 181, no. 2, 1979, pages 331 - 338, XP002684195, ISSN: 0264-6021
Attorney, Agent or Firm:
HUDDLESON, Justin, P. (Hall & Stewart LLPTwo International Plac, Boston MA, US)
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