Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID
Document Type and Number:
WIPO Patent Application WO/2011/075701
Kind Code:
A3
Abstract:
Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxysteroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

Inventors:
MORIARTY ROBERT M (US)
REID JOHN GREGORY (US)
SWARINGEN JR ROY A (US)
Application Number:
US2010/061150
Publication Date:
July 26, 2012
Filing Date:
December 17, 2010
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KYTHERA BIOPHARMACEUTICALS INC (US)
MORIARTY ROBERT M (US)
REID JOHN GREGORY (US)
SWARINGEN JR ROY A (US)
International Classes:
C07J1/00; C07J5/00; C07J9/00; C07J13/00; C07J41/00
Domestic Patent References:
WO2008157635A22008-12-24
Foreign References:
Other References:
A. KASAL: "Hydrogenation of 12-Oxo-5.beta.-chol-9(11)-enates on Platinum", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 46, 1981, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY, pages 1839 - 1849, XP002639976, ISSN: 0010-0765
SEGURA M ET AL: "Synthetic Receptors for Uronic Acid Salts Based on Bicyclic Guanidinium and Deoxycholic Acid Subunits", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 38, 22 September 1997 (1997-09-22), pages 13119 - 13128, XP004106213, ISSN: 0040-4020, DOI: DOI:10.1016/S0040-4020(97)00834-X
A. LARDON ET AL: "Über Bestandteile der Nebennierenrinde und verwandte Stoffe. 77 Mitteilung Ätiocholen-(11)-ol-(3.alpha.)-on-(17)", HELVETICA CHIMICA ACTA., vol. 30, 1947, CHVERLAG HELVETICA CHIMICA ACTA. BASEL., pages 1373 - 1378, XP002639977, ISSN: 0018-019X
H. REICH: "Über Bestandteile der Nebennierenrinde und verwandte Stoffe. 71 Mitteilung. Oxydation von Desoxycholsäure-methylester-diacetat mit Chromsäure. II. Einige Umwandlungsprodukte des Ätiocholandiol-(3.alpha.,12.beta.)-ons-(17)", HELVETICA CHIMICA ACTA., vol. 28, 1945, VERLAG HELVETICA CHIMICA ACTA., pages 863 - 872, XP002639978, ISSN: 0018-019X
TSERNG K-Y ET AL: "Bile acid sulfates. III. Synthesis of 7- and 12-monosulfates of bile acids and their conjugates using a sulfur trioxide-triethylamine complex", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 33, no. 2, 1 February 1979 (1979-02-01), pages 167 - 182, XP023431127, ISSN: 0039-128X, [retrieved on 19790201], DOI: DOI:10.1016/0039-128X(79)90024-2
GOTO J ET AL: "SYNTHESIS OF DISULFATES OF UNCONJUGATED AND CONJUGATED BILE ACIDS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 35, no. 11, 1 January 1987 (1987-01-01), pages 4562 - 4567, XP001157455, ISSN: 0009-2363
GOTO J ET AL: "Synthesis of monosulfates of unconjugated and conjugated bile acids.", CHEMICAL & PHARMACEUTICAL BULLETIN JUN 1979 LNKD- PUBMED:544053, vol. 27, no. 6, June 1979 (1979-06-01), pages 1402 - 1411, XP002639979, ISSN: 0009-2363
M. B. MEDER ET AL: "Co-ordination Chemistry of 1,3-Bis(2-pyridylimino)- and 1,3-Bis-(2-thiazolylimino) Copper Complexes: Investigation of Their Catalytic Behavior in Oxidation Reactions", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2004, pages 2716 - 2722, XP002639980
Attorney, Agent or Firm:
SWISS, Gerald F. et al. (975 Page Mill RoadPalo Alto, California, US)
Download PDF: