METHODS FOR THE PURIFICATION OF LEVOFLOXACIN

Title:

METHODS FOR THE PURIFICATION OF LEVOFLOXACIN

Document Type and Number:

WIPO Patent Application WO2003028665

Kind Code:

A3

Abstract:

Levofloxacin has been purified by dissolving levofloxacin in a polar solvent at an elevated temperature and crystallizing purified levofloxacin. Preferably, an antioxidant is added to increase the purity.

Inventors:

NIDDAM-HILDESHEIM VALERIE (IL)
GERSHON NEOMI (IL)
SCHWARTZ EDUARD (IL)

Application Number:

PCT/US2002/031851

Publication Date:

November 20, 2003

Filing Date:

October 03, 2002

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Assignee:

TEVA PHARMA (US)
TEVA PHARMA (US)
NIDDAM-HILDESHEIM VALERIE (IL)
GERSHON NEOMI (IL)
SCHWARTZ EDUARD (IL)

International Classes:

A61K31/5383; A61P31/04; B01D9/02; C07D498/06; (IPC1-7): C07D498/06

Foreign References:

US5545737A

1996-08-13

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