Title:
METHODS OF PURIFYING ADENO-ASSOCIATED VIRUS (AAV) AND/OR RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV)
Document Type and Number:
WIPO Patent Application WO/2016/114992
Kind Code:
A3
Abstract:
A method of purifying a viral vector is provided. The method includes loading a nonionic density gradient into a continuous flow centrifuge rotor; loading a material including the viral vector into the continuous flow centrifuge rotor; rotating the continuous flow centrifuge rotor in a manner sufficient to separate the viral vector and a predictable contaminate from the material in the nonionic density gradient; and unloading the separated viral vector and the predicable contaminant from the continuous flow centrifuge rotor.
Inventors:
MERIÑO SANDRA PATRICIA (NL)
CHEN HAIFENG (US)
CHEN HAIFENG (US)
Application Number:
PCT/US2016/012680
Publication Date:
September 22, 2016
Filing Date:
January 08, 2016
Export Citation:
Assignee:
ALFA WASSERMANN INC (US)
VIROVEK INC (US)
VIROVEK INC (US)
International Classes:
C07K1/14; C07K4/02; C12N7/02; G01N33/53; G01N33/543
Domestic Patent References:
| WO2004083405A2 | 2004-09-30 |
Foreign References:
| US20040121444A1 | 2004-06-24 | |||
| US20090023197A1 | 2009-01-22 | |||
| US20050189305A1 | 2005-09-01 | |||
| US20020177215A1 | 2002-11-28 |
Other References:
See also references of EP 3245218A4
Attorney, Agent or Firm:
MCMAHON, Edward, L. (Greeley Ruggiero & Perle, L.L.P.,One Landmark Square, 10th Floo, Stamford CT, US)
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