Title:
METHODS OF PURIFYING ANTI A BETA ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2006138737
Kind Code:
A8
Abstract:
The present application provides methods of purifying Aß binding proteins having a Fc region, for example, anti-Aß antibodies or antibody fusions, by adsorbing the Aß binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed Aß binding protein. The present application also features methods of eluting the purified Aß binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
Inventors:
GODAVARTI RANGANATHAN (US)
ISKRA TIMOTHY (US)
ISKRA TIMOTHY (US)
Application Number:
PCT/US2006/024026
Publication Date:
December 13, 2007
Filing Date:
June 16, 2006
Export Citation:
Assignee:
ELAN PHARMA INT LTD (IE)
WYETH CORP (US)
GODAVARTI RANGANATHAN (US)
ISKRA TIMOTHY (US)
WYETH CORP (US)
GODAVARTI RANGANATHAN (US)
ISKRA TIMOTHY (US)
International Classes:
A61K39/395; C07K16/18
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