Title:
METHODS FOR QUANTITATION OF INSULIN AND C-PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2018/183966
Kind Code:
A3
Abstract:
Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C- peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
Inventors:
SHIFFMAN DOV (US)
TONG CARMEN (US)
DEVLIN JAMES J (US)
MCPHAUL MICHAEL J (US)
TONG CARMEN (US)
DEVLIN JAMES J (US)
MCPHAUL MICHAEL J (US)
Application Number:
PCT/US2018/025575
Publication Date:
January 17, 2019
Filing Date:
March 30, 2018
Export Citation:
Assignee:
QUEST DIAGNOSTICS INVEST LLC (US)
International Classes:
G01N33/68; G01N33/70
Domestic Patent References:
| WO2012092281A2 | 2012-07-05 | |||
| WO2014105858A1 | 2014-07-03 |
Foreign References:
| US20160282328A1 | 2016-09-29 | |||
| US20150362510A1 | 2015-12-17 |
Other References:
KIPPEN, ALISTAIR D. ET AL.: "Development of an isotope dilution assay for precise determination of insulin, C-peptide, and proinsulin levels in non-diabetic and type II diabetic individuals with comparison to immunoassay", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 19, 1997, pages 12513 - 12522, XP002272400, DOI: doi:10.1074/jbc.272.19.12513
Attorney, Agent or Firm:
KIM, Joshua E. et al. (US)
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