Title:
METHODS FOR REDUCING AN ADVERSE IMMUNE RESPONSE TO A FOREIGN ANTIGEN IN HUMAN USING CD4-BINDING MOLECULES
Document Type and Number:
WIPO Patent Application WO/2012/145238
Kind Code:
A3
Abstract:
Provided are methods of inducing tolerance or reducing an immune response to a foreign antigen in a human subject. The methods include administering anti-CD4 antibodies or CD4-binding fragments thereof or CD4-binding molecules, and the foreign antigen to the human subject. Detailed dosing regimens including tolerizing window, individual dosage and total dosage, as well as dosing based on the blood concentration of the anti-CD4 antibodies or CD4-binding molecules are further described.
Inventors:
PONATH PAUL (US)
ROSENZWEIG MICHAEL (US)
VAICKUS LOU (US)
ROSENZWEIG MICHAEL (US)
VAICKUS LOU (US)
Application Number:
PCT/US2012/033483
Publication Date:
March 06, 2014
Filing Date:
April 13, 2012
Export Citation:
Assignee:
LIQUIDATING TRUST (US)
PONATH PAUL (US)
ROSENZWEIG MICHAEL (US)
VAICKUS LOU (US)
PONATH PAUL (US)
ROSENZWEIG MICHAEL (US)
VAICKUS LOU (US)
International Classes:
A61K39/00; A61K39/395
Foreign References:
| US20060002921A1 | 2006-01-05 | |||
| US20080160016A1 | 2008-07-03 | |||
| US20070166307A1 | 2007-07-19 | |||
| US20080112949A1 | 2008-05-15 |
Other References:
QI ET AL.: "Single dose anti-CD4 monoclonal antibody for induction of tolerance to cardiac allograft in high- and low-responder rat strain combinations.", TRANSPL IMMUNOL., vol. 5, no. 3, 1997, pages 204 - 11, XP055137861
Attorney, Agent or Firm:
MCCORMICK GRAHAM, Monica et al. (P.O. Box 1022Minneapolis, Minnesota, US)
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