Title:
METHODS FOR REDUCING CHOLESTEROL USING BACILLUS COAGULANS SPORES, SYSTEMS AND COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO1999049877
Kind Code:
A3
Abstract:
The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a bifidogenic oligosaccharides or other cholesterol-reducing agents for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.
Inventors:
FARMER SEAN (US)
LEFKOWITZ ANDREW R (US)
LEFKOWITZ ANDREW R (US)
Application Number:
PCT/US1999/007360
Publication Date:
December 16, 1999
Filing Date:
April 01, 1999
Export Citation:
Assignee:
GANEDEN BIOTECH INC (US)
FARMER SEAN (US)
LEFKOWITZ ANDREW R (US)
FARMER SEAN (US)
LEFKOWITZ ANDREW R (US)
International Classes:
A23L1/30; A61K35/10; A61K35/74; A61K35/742; A61K35/745; A61K35/747; A61K36/28; A23L1/28; A61K45/00; A61P3/06; A61P3/10; A61P9/10; C12N1/20; (IPC1-7): A61K35/74
Foreign References:
| EP0457539A1 | 1991-11-21 | |||
| EP0307158A2 | 1989-03-15 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 011, no. 259 (C - 441) 21 August 1987 (1987-08-21)
G. MOLIN ET AL.: "EFFECT OF FERMENTED OATMEAL SOUP ON THE CHOLESTEROL LEVEL AND THE LACTOBACILLUS COLONIZATION OF RAT INTESTINAL MUCOSA", ANTONIE VAN LEEUWENHOEK, vol. 61, no. 3, 1992, AMSTERDAM, NL, pages 167 - 173, XP002119334
J.C. MOHAN ET AL.: "PRELIMINARY OBSERVATIONS ON EFFECT OF LACTOBACILLUS SPOROGENES ON SERUM LIPID LEVELS IN HYPERCHOLESTEROLEMIC PATIENTS.", THE INDIAN JOURNAL OF MEDICAL RESEARCH, vol. 92, 1990, NEW DELHI, pages 431 - 432, XP002119335
G. SCHAAFSMA ET AL.: "EFFECTS OF A MILK PRODUCT, FERMENTED BY LACTOBACILLUS ACIDOPHILUS AND WITH FRUCTO-OLIGOSACCHARIDES ADDED, ON BLOOD LIPIDS IN MALE VOLUNTEERS.", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 52, no. 6, June 1998 (1998-06-01), LONDON, GB, pages 436 - 440, XP002119336
G. MOLIN ET AL.: "EFFECT OF FERMENTED OATMEAL SOUP ON THE CHOLESTEROL LEVEL AND THE LACTOBACILLUS COLONIZATION OF RAT INTESTINAL MUCOSA", ANTONIE VAN LEEUWENHOEK, vol. 61, no. 3, 1992, AMSTERDAM, NL, pages 167 - 173, XP002119334
J.C. MOHAN ET AL.: "PRELIMINARY OBSERVATIONS ON EFFECT OF LACTOBACILLUS SPOROGENES ON SERUM LIPID LEVELS IN HYPERCHOLESTEROLEMIC PATIENTS.", THE INDIAN JOURNAL OF MEDICAL RESEARCH, vol. 92, 1990, NEW DELHI, pages 431 - 432, XP002119335
G. SCHAAFSMA ET AL.: "EFFECTS OF A MILK PRODUCT, FERMENTED BY LACTOBACILLUS ACIDOPHILUS AND WITH FRUCTO-OLIGOSACCHARIDES ADDED, ON BLOOD LIPIDS IN MALE VOLUNTEERS.", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 52, no. 6, June 1998 (1998-06-01), LONDON, GB, pages 436 - 440, XP002119336
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