Title:
METHODS RELATED TO THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY CONDITIONS
Document Type and Number:
WIPO Patent Application WO2005112931
Kind Code:
A3
Abstract:
The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.
Inventors:
HONG JAU-SHYONG (US)
QIN LIYA (US)
LI GUORONG (US)
BLOCK MICHELLE (US)
ZHANG WEI (US)
CHEN PO-SEE (US)
PENG GIIA-SHUEN
QIN LIYA (US)
LI GUORONG (US)
BLOCK MICHELLE (US)
ZHANG WEI (US)
CHEN PO-SEE (US)
PENG GIIA-SHUEN
Application Number:
PCT/US2005/016691
Publication Date:
June 01, 2006
Filing Date:
May 12, 2005
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
HONG JAU-SHYONG (US)
QIN LIYA (US)
LI GUORONG (US)
BLOCK MICHELLE (US)
ZHANG WEI (US)
CHEN PO-SEE (US)
PENG GIIA-SHUEN
HONG JAU-SHYONG (US)
QIN LIYA (US)
LI GUORONG (US)
BLOCK MICHELLE (US)
ZHANG WEI (US)
CHEN PO-SEE (US)
PENG GIIA-SHUEN
International Classes:
A61K31/485; A61K38/00; A61K38/06; A61K38/08; A61K38/33; A61P29/00
Domestic Patent References:
| WO2002102989A2 | 2002-12-27 | |||
| WO2000038669A2 | 2000-07-06 |
Foreign References:
| US6586443B1 | 2003-07-01 | |||
| US5166207A | 1992-11-24 | |||
| US5229394A | 1993-07-20 | |||
| US4994466A | 1991-02-19 | |||
| EP0377272A2 | 1990-07-11 |
Other References:
CRUCIANI R A ET AL: "Ultra-low dose oral naltrexone decreases side effects and potentiates the effect of methadone [1]", JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 01 JUN 2003 UNITED STATES, vol. 25, no. 6, 1 June 2003 (2003-06-01), pages 491 - 494, XP008058685, ISSN: 0885-3924
HAMANN SCOTT R ET AL: "Ultra-low dose of naltrexone attenuates neuropathic but not acute pain in rats", FASEB JOURNAL, vol. 18, no. 4-5, 2004, & FASEB MEETING ON EXPERIMENTAL BIOLOGY: TRANSLATING THE GENOME; WASHINGTON, DISTRICT OF COLUMBIA, USA; APRIL 17-21, 2004, pages Abst. 635.8 URL - http://ww, XP008058694, ISSN: 0892-6638
MAKMAN MAYNARD H ET AL: "Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus", BRAIN RESEARCH, vol. 762, no. 1-2, 1997, pages 247 - 250, XP008058699, ISSN: 0006-8993
KANEIDER NICOLE C ET AL: "Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration.", BIOCHEMISTRY, vol. 43, no. 1, 13 January 2004 (2004-01-13), pages 237 - 244, XP008058734, ISSN: 0006-2960
QIN LIYA ET AL: "Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress", FASEB JOURNAL, vol. 19, no. 6, April 2005 (2005-04-01), pages 550 - 557, XP008058703, ISSN: 0892-6638
HAMANN SCOTT R ET AL: "Ultra-low dose of naltrexone attenuates neuropathic but not acute pain in rats", FASEB JOURNAL, vol. 18, no. 4-5, 2004, & FASEB MEETING ON EXPERIMENTAL BIOLOGY: TRANSLATING THE GENOME; WASHINGTON, DISTRICT OF COLUMBIA, USA; APRIL 17-21, 2004, pages Abst. 635.8 URL - http://ww, XP008058694, ISSN: 0892-6638
MAKMAN MAYNARD H ET AL: "Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus", BRAIN RESEARCH, vol. 762, no. 1-2, 1997, pages 247 - 250, XP008058699, ISSN: 0006-8993
KANEIDER NICOLE C ET AL: "Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration.", BIOCHEMISTRY, vol. 43, no. 1, 13 January 2004 (2004-01-13), pages 237 - 244, XP008058734, ISSN: 0006-2960
QIN LIYA ET AL: "Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress", FASEB JOURNAL, vol. 19, no. 6, April 2005 (2005-04-01), pages 550 - 557, XP008058703, ISSN: 0892-6638
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