Title:
METHODS FOR SCREENING CEREBLON MODIFYING COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/140088
Kind Code:
A1
Abstract:
A method of screening a cereblon modifying compound for treating a disease or disorder, comprising: obtaining a sample; determining a first protein level of SALL4; administering the cereblon modifying compound to the sample; determining a second protein level of SALL4; comparing the first level and the second protein level of SALL4 to determine if the cereblon modifying compound induces degradation of SALL4; and selecting the cereblon modifying compound that does not induce degradation of SALL4.
Inventors:
MATYSKIELA MARY (US)
CHAMBERLAIN PHILIP (US)
COUTO SUZANA (US)
LU GANG (US)
STAMP KATHERINE (US)
SHERRATT PHILIP (US)
HUI JULIA (US)
CHAMBERLAIN PHILIP (US)
COUTO SUZANA (US)
LU GANG (US)
STAMP KATHERINE (US)
SHERRATT PHILIP (US)
HUI JULIA (US)
Application Number:
PCT/US2019/013049
Publication Date:
July 18, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
CELGENE CORP (US)
International Classes:
G01N33/50; A61K45/06
Domestic Patent References:
| WO2017161119A1 | 2017-09-21 |
Foreign References:
| US20080241110A1 | 2008-10-02 | |||
| US20040265230A1 | 2004-12-30 |
Other References:
KNOBLOCH ET AL.: "Shedding light on an old mystery: Thalidomide suppresses survival pathways to induce limb defects", CELL CYCLE, vol. 7, no. 9, 1 May 2008 (2008-05-01), pages 1121 - 1127, XP055607446, doi:10.4161/cc.7.9.5793
See also references of EP 3737946A4
See also references of EP 3737946A4
Attorney, Agent or Firm:
LIANG, Bing et al. (US)
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