Title:
METHODS OF SCREENING COMPOUNDS FOR GRK6 MODULATING ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004004451
Kind Code:
B1
Abstract:
The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.
Inventors:
CARON MARC G (US)
GAINETDINOV RAUL R (US)
LEFKOWITZ ROBERT J (US)
PREMONT RICHARD T (US)
GAINETDINOV RAUL R (US)
LEFKOWITZ ROBERT J (US)
PREMONT RICHARD T (US)
Application Number:
PCT/US2003/020838
Publication Date:
April 15, 2004
Filing Date:
July 03, 2003
Export Citation:
Assignee:
UNIV DUKE (US)
CARON MARC G (US)
GAINETDINOV RAUL R (US)
LEFKOWITZ ROBERT J (US)
PREMONT RICHARD T (US)
CARON MARC G (US)
GAINETDINOV RAUL R (US)
LEFKOWITZ ROBERT J (US)
PREMONT RICHARD T (US)
International Classes:
A01K67/027; A61K31/7088; A61K45/00; A61K48/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/30; A61P43/00; C07K14/705; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12N15/85; C12Q1/02; G01N33/15; G01N33/50; G01N33/573; G01N33/74; (IPC1-7): A01K67/00; C12N9/12; G01N33/00
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