Title:
METHODS OF SEQUENCING THE IMMUNE REPERTOIRE
Document Type and Number:
WIPO Patent Application WO/2014/144713
Kind Code:
A3
Abstract:
The invention provides a non-invasive technique for the detection and quantification of the immune repertoire, in a biological sample containing a plurality of distinct cell populations. Methods are conducted using sequencing technology to detect and enumerate immune repertoire within a heterogeneous biological sample.
Inventors:
HUTCHINS EDWARD A (US)
FAN HEI-MUN CHRISTINA (US)
FAN HEI-MUN CHRISTINA (US)
Application Number:
PCT/US2014/029241
Publication Date:
November 27, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
LINEAGE BIOSCIENCES INC (US)
International Classes:
C12N15/10; C12Q1/68
Domestic Patent References:
| WO2012083069A2 | 2012-06-21 | |||
| WO2011140433A2 | 2011-11-10 | |||
| WO1997024455A2 | 1997-07-10 | |||
| WO2004024953A1 | 2004-03-25 | |||
| WO2005019452A1 | 2005-03-03 | |||
| WO2005059176A1 | 2005-06-30 |
Other References:
JIANG NING ET AL: "Lineage structure of the human antibody repertoire in response to influenza vaccination.", SCIENCE TRANSLATIONAL MEDICINE 6 FEB 2013, vol. 5, no. 171, 6 February 2013 (2013-02-06), pages 171ra19, XP009180301, ISSN: 1946-6242
GUIDO SCHRAMM ET AL: "A simple and reliable 5'-RACE approach", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 28, no. 22, 15 November 2000 (2000-11-15), pages 1 - 4, XP002661255, ISSN: 1362-4962
WANG ENA ET AL: "high-fidelity mRNA amplification for gene profiling", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 18, 1 April 2000 (2000-04-01), pages 457 - 459, XP002211679, ISSN: 1087-0156, DOI: 10.1038/74546
GEORGIOU GEORGE ET AL: "The promise and challenge of high-throughput sequencing of the antibody repertoire.", NATURE BIOTECHNOLOGY FEB 2014, vol. 32, no. 2, February 2014 (2014-02-01), pages 158 - 168, XP002730089, ISSN: 1546-1696
GUIDO SCHRAMM ET AL: "A simple and reliable 5'-RACE approach", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, GB, vol. 28, no. 22, 15 November 2000 (2000-11-15), pages 1 - 4, XP002661255, ISSN: 1362-4962
WANG ENA ET AL: "high-fidelity mRNA amplification for gene profiling", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 18, 1 April 2000 (2000-04-01), pages 457 - 459, XP002211679, ISSN: 1087-0156, DOI: 10.1038/74546
GEORGIOU GEORGE ET AL: "The promise and challenge of high-throughput sequencing of the antibody repertoire.", NATURE BIOTECHNOLOGY FEB 2014, vol. 32, no. 2, February 2014 (2014-02-01), pages 158 - 168, XP002730089, ISSN: 1546-1696
Attorney, Agent or Firm:
FLANAGAN, Lisa, D. et al. (Two Embarcadero Center Eighth Floo, San Francisco CA, US)
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