Title:
METHODS FOR SYNTHESIZING NUCLEOSIDES, NUCLEOSIDE DERIVATIVES AND NON-NUCLEOSIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002018405
Kind Code:
A3
Abstract:
The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.
Inventors:
BEIGELMAN LEONID (US)
KARPEISKY ALEXANDER (US)
SEREBRYANY VLADIMIR (US)
HAEBERLI PETER (US)
SWEEDLER DAVID (US)
KARPEISKY ALEXANDER (US)
SEREBRYANY VLADIMIR (US)
HAEBERLI PETER (US)
SWEEDLER DAVID (US)
Application Number:
PCT/US2001/027116
Publication Date:
January 03, 2003
Filing Date:
August 31, 2001
Export Citation:
Assignee:
RIBOZYME PHARM INC (US)
BEIGELMAN LEONID (US)
KARPEISKY ALEXANDER (US)
SEREBRYANY VLADIMIR (US)
HAEBERLI PETER (US)
SWEEDLER DAVID (US)
BEIGELMAN LEONID (US)
KARPEISKY ALEXANDER (US)
SEREBRYANY VLADIMIR (US)
HAEBERLI PETER (US)
SWEEDLER DAVID (US)
International Classes:
C07H11/04; C07H15/00; C07H19/06; C07H19/10; C07H19/067; C07H19/16; C07H19/167; C07H19/20; C07H23/00; (IPC1-7): C07H19/06; C07H19/16; A61K31/7052; C12Q1/68
Domestic Patent References:
WO1997026270A2 | 1997-07-24 |
Other References:
WADA T ET AL: "Regioselective Protection of the 2'-Hydroxyl Group of N-Acyl-3',5'-O-di(t-butyl)silanediylnucleoside Derivatives by Use of t-BuMgCl and 2-(Trimethylsilyl)ethoxymethyl Chloride", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 10, 6 March 1995 (1995-03-06), pages 1683 - 1684, XP004028564, ISSN: 0040-4039
A. KARPEISKY ET AL.: "2'-O-Methylthiomethyl modifications in hammerhead ribozymes", NUCLEOSIDES & NUCLEOTIDES, vol. 16, 1997, pages 955 - 958, XP002202372
GROTLI M ET AL: "2'-O-(Carbamoylmethyl)oligoribonucleotides", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 55, no. 14, April 1999 (1999-04-01), pages 4299 - 4314, XP004161108, ISSN: 0040-4020
M. GROTLI ET AL.: "Protection of the guanine residue during synthesis of 2'-O-alkylguanosine derivatives", J. CHEM. SOC., PERKIN TRANS. 1, 1997, pages 2779 - 2788, XP002202373
A. KARPEISKY ET AL.: "2'-O-Methylthiomethyl modifications in hammerhead ribozymes", NUCLEOSIDES & NUCLEOTIDES, vol. 16, 1997, pages 955 - 958, XP002202372
GROTLI M ET AL: "2'-O-(Carbamoylmethyl)oligoribonucleotides", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 55, no. 14, April 1999 (1999-04-01), pages 4299 - 4314, XP004161108, ISSN: 0040-4020
M. GROTLI ET AL.: "Protection of the guanine residue during synthesis of 2'-O-alkylguanosine derivatives", J. CHEM. SOC., PERKIN TRANS. 1, 1997, pages 2779 - 2788, XP002202373
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