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Title:
METHODS, SYSTEMS, AND COMPOSITIONS FOR PROMOTING BONE GROWTH
Document Type and Number:
WIPO Patent Application WO/2015/009991
Kind Code:
A3
Abstract:
The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.

Inventors:
BARRETT STEPHEN DOUGLAS (US)
COLOMBO JOSEPH MICHAEL (US)
GERMAIN BRADLEE DAVID (US)
KORNILOV ANDRIY (US)
KRAMER JAMES BEMARD (US)
UZIEBLO ADAM (US)
ENDRES GREGORY WILLIAM (US)
CISKE FRED LAWRENCE (US)
OWEN THOMAS ALLEN (US)
O'MALLEY JAMES PAUL (US)
Application Number:
PCT/US2014/047138
Publication Date:
July 16, 2015
Filing Date:
July 18, 2014
Export Citation:
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Assignee:
CAYMAN CHEMICAL CO INC (US)
MYOMETRICS LLC (US)
International Classes:
A61L27/24; A61L27/12; A61L27/36; A61L27/42; A61L27/54
Domestic Patent References:
WO2004078103A22004-09-16
Foreign References:
US20110237552A12011-09-29
EP1417975A12004-05-12
US20020065308A12002-05-30
Other References:
GINEBRA M P ET AL: "Calcium phosphate cements as bone drug delivery systems: A review", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 113, no. 2, 28 June 2006 (2006-06-28), pages 102 - 110, XP024957542, ISSN: 0168-3659, [retrieved on 20060628], DOI: 10.1016/J.JCONREL.2006.04.007
MASAHIRO TANAKA ET AL: "Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats", BONE, vol. 34, no. 6, 1 June 2004 (2004-06-01), pages 940 - 948, XP055155728, ISSN: 8756-3282, DOI: 10.1016/j.bone.2004.01.002
Attorney, Agent or Firm:
CARROLL, William, A. (P.O. Box 10087Chicago, IL, US)
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