Title:
METHODS AND SYSTEMS, FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED ANTIMICROBIALS AND COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2019/075202
Kind Code:
A3
Abstract:
Provided herein are methods, systems, and related compounds and compositions suitable for reducing antibiotic resistance and/or the survivability of Nar (cytoplasmic nitrate reductase)-and/or Nap (periplasmic nitrate reductase)-containing bacteria.
Inventors:
NEWMAN DIANNE K (US)
COATES JOHN (US)
SPERO MELANIE A (US)
COATES JOHN (US)
SPERO MELANIE A (US)
Application Number:
PCT/US2018/055416
Publication Date:
June 06, 2019
Filing Date:
October 11, 2018
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
UNIV CALIFORNIA (US)
UNIV CALIFORNIA (US)
International Classes:
A01N25/04; A01N59/00; A01N25/06; A01N25/34; A01N43/90
Foreign References:
| US20080299223A1 | 2008-12-04 |
Other References:
DATABASE Protein 6 February 2016 (2016-02-06), "nitrate reductase subunit alpha [Pseudomonas aeruginosa]", XP055615149, retrieved from NCBI Database accession no. WP_034074485.1
WOLTERINK, A.: "Characterization of (per) chlorate-reducing bacteria", THESIS, 2004, pages 1 - 138, XP055615153
KUCERA, I. ET AL.: "Interference of chlorate and chlorite with nitrate reduction in resting cells of Paracoccus denitrificans", MICROBIOLOGY, vol. 152, 2006, pages 3529 - 3534, XP055615156
BORRIELLO, G. ET AL.: "Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, no. 7, July 2004 (2004-07-01), pages 2659 - 2664, XP055615157
SPERO, M. A. ET AL.: "Chlorate specifically targets oxidant-starved, antibiotic-tolerant populations of Pseudomonas aeruginosa biofilms", AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 9, no. 5, 25 September 2018 (2018-09-25), pages 1 - 16, XP055615158
WOLTERINK, A.: "Characterization of (per) chlorate-reducing bacteria", THESIS, 2004, pages 1 - 138, XP055615153
KUCERA, I. ET AL.: "Interference of chlorate and chlorite with nitrate reduction in resting cells of Paracoccus denitrificans", MICROBIOLOGY, vol. 152, 2006, pages 3529 - 3534, XP055615156
BORRIELLO, G. ET AL.: "Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, no. 7, July 2004 (2004-07-01), pages 2659 - 2664, XP055615157
SPERO, M. A. ET AL.: "Chlorate specifically targets oxidant-starved, antibiotic-tolerant populations of Pseudomonas aeruginosa biofilms", AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 9, no. 5, 25 September 2018 (2018-09-25), pages 1 - 16, XP055615158
Attorney, Agent or Firm:
XU, Jiancong et al. (US)
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