Title:
METHODS, SYSTEMS, AND KITS FOR INTRAVASCULAR NUCLEIC ACID DELIVERY
Document Type and Number:
WIPO Patent Application WO1999033500
Kind Code:
A3
Abstract:
kucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm<2> to 100 W/cm<2>, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.
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Inventors:
NEWMAN CHRISTOPHER M H
BRISKEN AXEL F
BRISKEN AXEL F
Application Number:
PCT/US1998/027852
Publication Date:
September 16, 1999
Filing Date:
December 30, 1998
Export Citation:
Assignee:
PHARMASONICS INC (US)
International Classes:
A61F13/00; A61K9/22; A61M37/00; A61N1/32; A61M5/00; A61B17/22; (IPC1-7): A61N1/30; A61B17/20; A61M1/00; A61M29/00; A61M5/00; A61F13/00; A61K9/22
Foreign References:
| US5728062A | 1998-03-17 | |||
| US5735811A | 1998-04-07 | |||
| US5725494A | 1998-03-10 | |||
| US5328470A | 1994-07-12 |
Other References:
See also references of EP 1044035A4
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