Title:
METHODS OF TARGETING PTEN MUTANT DISEASES AND COMPOSITIONS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2012/000103
Kind Code:
A8
Abstract:
Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.
Inventors:
PAN GUOHUA (CA)
MASON JACQUELINE M (CA)
WEI XIN (CA)
FEHER MIKLOS (CA)
MASON JACQUELINE M (CA)
WEI XIN (CA)
FEHER MIKLOS (CA)
Application Number:
PCT/CA2011/000776
Publication Date:
March 01, 2012
Filing Date:
July 04, 2011
Export Citation:
Assignee:
UNIV HEALTH NETWORK (CA)
PAN GUOHUA (CA)
MASON JACQUELINE M (CA)
WEI XIN (CA)
FEHER MIKLOS (CA)
PAN GUOHUA (CA)
MASON JACQUELINE M (CA)
WEI XIN (CA)
FEHER MIKLOS (CA)
International Classes:
A61K31/496; A61K31/415; A61K31/4155; A61K31/4439; A61P35/00
Attorney, Agent or Firm:
ERRAT, Judy, A. et al. (160 Elgin Street Suite 260, Ottawa Ontario K1P 1C3, CA)
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