Title:
METHODS OF THROMBOLYTIC ORGAN TREATMENT AND REPAIR
Document Type and Number:
WIPO Patent Application WO2002017714
Kind Code:
A3
Abstract:
The invention teaches methods and compositions for removing thrombi lodged in the microvasculature of an organ. To remove the thrombi, the organ may be perfused, flushed or washed with a suitable perfusion solution to which a sufficient amount of a thrombolytic agent, such as Streptokinase, has been added. The perfusing, flushing or washing process of the organ with the thrombolytic agent will promote thrombolysis on existing thrombi, prevent the formation of new thrombi in the organ, and/or open the vasculature of the organ thereby decreasing vascular resistance and increasing flow. The method of the invention may be practiced using an organ perfusion apparatus that would allow the viability of the organ to be sustained and/or restored upon perfusion with a thrombolytic agent.
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Inventors:
GAGE FREDERICK A
BATTJES-SILER DEBRA J
BATTJES-SILER DEBRA J
Application Number:
PCT/US2001/026401
Publication Date:
August 08, 2002
Filing Date:
August 24, 2001
Export Citation:
Assignee:
ORGAN RECOVERY SYSTEMS INC (US)
International Classes:
A01N1/02; (IPC1-7): A01N1/02; A61B17/00
Foreign References:
| EP0451880A2 | 1991-10-16 | |||
| EP0407780A2 | 1991-01-16 | |||
| US5843024A | 1998-12-01 | |||
| US6046046A | 2000-04-04 |
Other References:
DATABASE MEDLINE [online] May 1992 (1992-05-01), GUNDRY S R ET AL: "Successful transplantation of hearts harvested 30 minutes after death from exsanguination.", XP002197558, Database accession no. NLM1570968
DATABASE MEDLINE [online] 15 May 2000 (2000-05-15), YAMAUCHI J I ET AL: "Warm preflush with streptokinase improves microvascular procurement and tissue integrity in liver graft retrieval from non-heart-beating donors.", XP002197559, Database accession no. NLM10830211
DATABASE MEDLINE [online] August 1977 (1977-08-01), LIMAS C ET AL: "Histologic changes in preserved cadaveric renal transplants.", XP002197560, Database accession no. NLM327827
DATABASE MEDLINE [online] 15 May 2000 (2000-05-15), YAMAUCHI J I ET AL: "Warm preflush with streptokinase improves microvascular procurement and tissue integrity in liver graft retrieval from non-heart-beating donors.", XP002197559, Database accession no. NLM10830211
DATABASE MEDLINE [online] August 1977 (1977-08-01), LIMAS C ET AL: "Histologic changes in preserved cadaveric renal transplants.", XP002197560, Database accession no. NLM327827
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