Title:
METHODS TO PREDICT SPERM RETRIEVAL IN MALES
Document Type and Number:
WIPO Patent Application WO/2012/129048
Kind Code:
A3
Abstract:
The expression level of heat shock factor Y chromosome (HSFY) in testicular tissue samples or semen predicts the outcome of testicular sperm extraction in patients with all histological variants of nonobstructive azoospermia.
Inventors:
STAHL PETER J (US)
SCHLEGEL PETER N (US)
PADUCH DARIUS A (US)
SCHLEGEL PETER N (US)
PADUCH DARIUS A (US)
Application Number:
PCT/US2012/029239
Publication Date:
January 03, 2013
Filing Date:
March 15, 2012
Export Citation:
Assignee:
STAHL PETER J (US)
SCHLEGEL PETER N (US)
PADUCH DARIUS A (US)
SCHLEGEL PETER N (US)
PADUCH DARIUS A (US)
International Classes:
C12Q1/68; C12N15/11; G01N33/53; G01N33/543
Foreign References:
| US5871920A | 1999-02-16 | |||
| US20100130859A1 | 2010-05-27 |
Other References:
STAHL, P. J. ET AL.: "Testicular expression analysis of the AZF genes in azoospermic men suggests essentially and specific function for DDX3Y, RPS4Y2, CDY2, and HSFY", FERTILITY AND STERILITY, vol. 94, September 2010 (2010-09-01), pages S232
TESSARI, A. ET AL.: "Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis", MOLECULAR HUMAN REPRODUCTION, vol. 10, no. 4, 16 February 2004 (2004-02-16), pages 253 - 258
STAHL, P. J. ET AL.: "Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia", FERTILITY AND STERILITY, vol. 96, no. 2, August 2011 (2011-08-01), pages 303 - 308
TESSARI, A. ET AL.: "Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis", MOLECULAR HUMAN REPRODUCTION, vol. 10, no. 4, 16 February 2004 (2004-02-16), pages 253 - 258
STAHL, P. J. ET AL.: "Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia", FERTILITY AND STERILITY, vol. 96, no. 2, August 2011 (2011-08-01), pages 303 - 308
Attorney, Agent or Firm:
MADDEN, Robert B. et al. (Lundberg & Woessner P.A.,P.O. Box 293, Minneapolis Minnesota, US)
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