METHODS FOR TREATING AUTOIMMUNE DISEASES IN A SUBJECT AND IN VITRO DIAGNOSTIC ASSAYS

Title:

METHODS FOR TREATING AUTOIMMUNE DISEASES IN A SUBJECT AND IN VITRO DIAGNOSTIC ASSAYS

Document Type and Number:

WIPO Patent Application WO2002067760

Kind Code:

A3

Abstract:

The invention provides a method for treating an autoimmune disease in a subject by administering an interferon antagonist and a Flt3 ligand (Flt3L) antagonist. The invention also provides compositions containing one or more interferon antagonists, and one or more Flt3L antagonists, an in vitro assay for determining a subject's risk for developing an autoimmune disease, and kits for use, inter alia, with the assay.

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Inventors:

BANCHEREAU JACQUES F
PALUCKA ANNA KAROLINA
BLANCO PATRICK

Application Number:

PCT/US2002/000343

Publication Date:

March 13, 2003

Filing Date:

January 08, 2002

Export Citation:

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Assignee:

BAYLOR RES INST (US)

International Classes:

A61K38/00; A61K38/17; A61K38/19; A61K38/21; A61K39/395; A61K45/06; G01N33/53; A61P3/10; A61P7/00; A61P7/06; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P29/00; A61P31/00; A61P31/18; A61P37/06; C07K16/22; C07K16/24; C07K16/40; G01N21/76; G01N21/78; G01N33/564; G01N33/577; G01N33/58; G01N33/68; (IPC1-7): A61K39/38; A61K39/00; A61K38/19; A61K38/21; A61K38/40; A61K39/42

Foreign References:

US5888511A	1999-03-30
US5889151A	1999-03-30
EP0627487A2	1994-12-07
US5919452A	1999-07-06

Other References:

HUANG X. ET AL.: "Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice", IMMUNITY, vol. 1, no. 6, September 1994 (1994-09-01), pages 469 - 478, XP002957264
SOOS ET AL.: "Oral feeding of interferon tou can prevent the acute and chronic relapsing forms of experimental allergic encephalomyelitis", J. NEUROIMMUNOLOGY, vol. 75, no. 1-2, May 1997 (1997-05-01), pages 43 - 50, XP000676399

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