Title:
METHODS FOR TREATING BACTERIAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2021/115415
Kind Code:
A1
Abstract:
Methods and compositions for treating and/or preventing a bacterial infection in a subject are provided, in which the subject is administered a fecal sample obtained from a donor subject via fecal microbiota transplantation (FMT). The fecal sample contains bacteriophages that target the bacteria causing the infection. In some embodiments, the fecal sample containing the bacteriophages can be obtained from a donor subject who previously had the same infection but is now cured.
Inventors:
NG SIEW CHIEN (CN)
CHAN KA LEUNG (CN)
LIU QIN (CN)
CHAN KA LEUNG (CN)
LIU QIN (CN)
Application Number:
PCT/CN2020/135614
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
MICROBIOTA I CENTER MAGIC LTD (CN)
International Classes:
A61K35/24; A61K35/76; A61P1/00; C12Q1/70
Domestic Patent References:
| WO2014078911A1 | 2014-05-30 | |||
| WO2017075098A1 | 2017-05-04 |
Other References:
TAO ZUO ET AL: "Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 67, 15 May 2017 (2017-05-15), UK, pages 634 - 643, XP055714979, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-313952
L.A. DRAPER;F.J. RYAN;M.K. SMITH;J. JALANKA;E. MATTILA;P.A. ARKKILA;R.P. ROSS;R. SATOKARI;C. HILL: "Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation", MICROBIOME, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 10 December 2018 (2018-12-10), London, UK, pages 1 - 9, XP021263381, DOI: 10.1186/s40168-018-0598-x
PARK HEEKUK, LAFFIN MICHAEL R., JOVEL JUAN, MILLAN BRADEN, HYUN JAE E., HOTTE NAOMI, KAO DINA, MADSEN KAREN L.: "The success of fecal microbial transplantation in Clostridium difficile infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study", GUT MICROBES, LANDES BIOSCIENCE, UNITED STATES, vol. 10, no. 6, 2 November 2019 (2019-11-02), United States, pages 676 - 687, XP055820777, ISSN: 1949-0976, DOI: 10.1080/19490976.2019.1586037
NG，S.C. ET AL.: "Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)，", GUT, vol. 69, 14 October 2019 (2019-10-14), XP055714992, DOI: 10.1136/gutjnl-2019-319407
AGATA KĘSIK-SZELOCH;ZUZANNA DRULIS-KAWA;BEATA WEBER-DĄBROWSKA;JERZY KASSNER;GRAŻYNA MAJKOWSKA-SKROBEK;DARIA AUGUSTYNIAK;MARZANNA Ł: "Characterising the biology of novel lytic bacteriophages infecting multidrug resistant Klebsiella pneumoniae", VIROLOGY JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 28 March 2013 (2013-03-28), GB, pages 100, XP021147097, ISSN: 1743-422X, DOI: 10.1186/1743-422X-10-100
HESSE SHAYLA, MALACHOWA NATALIA, PORTER ADELINE, FREEDMAN BRETT, BS, KOBAYASHI SCOTT, ADHYA SANKAR, DELEO FRANK, BOBILEV DMITRI, B: "1952. Bacteriophage Treatment Improves Survival of Mice Infected with Carbapenem-Resistant Klebsiella pneumoniae", OPEN FORUM INFECTIOUS DISEASES, vol. 6, no. Suppl.2, 23 October 2019 (2019-10-23), pages s60, XP055820779
LUI: "History of Changes for Study: NCT03479710", 25 March 2018 (2018-03-25), XP055820780, Retrieved from the Internet [retrieved on 20210705]
L.A. DRAPER;F.J. RYAN;M.K. SMITH;J. JALANKA;E. MATTILA;P.A. ARKKILA;R.P. ROSS;R. SATOKARI;C. HILL: "Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation", MICROBIOME, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 10 December 2018 (2018-12-10), London, UK, pages 1 - 9, XP021263381, DOI: 10.1186/s40168-018-0598-x
PARK HEEKUK, LAFFIN MICHAEL R., JOVEL JUAN, MILLAN BRADEN, HYUN JAE E., HOTTE NAOMI, KAO DINA, MADSEN KAREN L.: "The success of fecal microbial transplantation in Clostridium difficile infection correlates with bacteriophage relative abundance in the donor: a retrospective cohort study", GUT MICROBES, LANDES BIOSCIENCE, UNITED STATES, vol. 10, no. 6, 2 November 2019 (2019-11-02), United States, pages 676 - 687, XP055820777, ISSN: 1949-0976, DOI: 10.1080/19490976.2019.1586037
NG，S.C. ET AL.: "Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)，", GUT, vol. 69, 14 October 2019 (2019-10-14), XP055714992, DOI: 10.1136/gutjnl-2019-319407
AGATA KĘSIK-SZELOCH;ZUZANNA DRULIS-KAWA;BEATA WEBER-DĄBROWSKA;JERZY KASSNER;GRAŻYNA MAJKOWSKA-SKROBEK;DARIA AUGUSTYNIAK;MARZANNA Ł: "Characterising the biology of novel lytic bacteriophages infecting multidrug resistant Klebsiella pneumoniae", VIROLOGY JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 28 March 2013 (2013-03-28), GB, pages 100, XP021147097, ISSN: 1743-422X, DOI: 10.1186/1743-422X-10-100
HESSE SHAYLA, MALACHOWA NATALIA, PORTER ADELINE, FREEDMAN BRETT, BS, KOBAYASHI SCOTT, ADHYA SANKAR, DELEO FRANK, BOBILEV DMITRI, B: "1952. Bacteriophage Treatment Improves Survival of Mice Infected with Carbapenem-Resistant Klebsiella pneumoniae", OPEN FORUM INFECTIOUS DISEASES, vol. 6, no. Suppl.2, 23 October 2019 (2019-10-23), pages s60, XP055820779
LUI: "History of Changes for Study: NCT03479710", 25 March 2018 (2018-03-25), XP055820780, Retrieved from the Internet
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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