METHODS OF TREATING CANCER AND RELATED METHODS

Title:

METHODS OF TREATING CANCER AND RELATED METHODS

Document Type and Number:

WIPO Patent Application WO2004043389

Kind Code:

B1

Abstract:

Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one and determining a metabolic profile therefore.

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Inventors:

MACHAJEWSKI TIMOTHY D (US)
HANNAH ALISON (US)
HARWOOD ERIC (US)
HAROLDSEN PETER (US)
HEISE CARLA C (US)
SAMARA EMIL (US)
SHANG XIAO (US)
VORA JAYESH (US)
ZHU SHUGUANG (US)

Application Number:

PCT/US2003/035806

Publication Date:

September 16, 2004

Filing Date:

November 12, 2003

Export Citation:

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Assignee:

CHIRON CORP (US)
MACHAJEWSKI TIMOTHY D (US)
HANNAH ALISON (US)
HARWOOD ERIC (US)
HAROLDSEN PETER (US)
HEISE CARLA C (US)
SAMARA EMIL (US)
SHANG XIAO (US)
VORA JAYESH (US)
ZHU SHUGUANG (US)

International Classes:

A61K9/00; A61K31/4375; A61K31/4709; A61K31/496; A61K31/52; A61K47/26; A61P35/00; C07D401/04; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D453/02; C07D453/06; C07D471/04; (IPC1-7): A61K31/496; C07D401/14

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