Title:
METHODS OF TREATING CANCER USING AND AGENT THAT MODULATES ACTIVITY OF THE CALCITONIN-GENE RELATED PEPTIDE ("CGRP") RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2010/006168
Kind Code:
A3
Abstract:
The present invention is directed to methods of treating cancer and preventing cancer metastasis in a subject by administering a modulator of CGRP receptor signaling. The present invention is further directed to methods of identifying novel compounds that inhibit CGRP receptor signaling.
Inventors:
DICKERSON IAN M (US)
BROWN EDWARD B (US)
BROWN EDWARD B (US)
Application Number:
PCT/US2009/050103
Publication Date:
March 11, 2010
Filing Date:
July 09, 2009
Export Citation:
Assignee:
UNIV ROCHESTER (US)
DICKERSON IAN M (US)
BROWN EDWARD B (US)
DICKERSON IAN M (US)
BROWN EDWARD B (US)
International Classes:
A61K39/00; A61K39/395
Foreign References:
| US20020164707A1 | 2002-11-07 | |||
| US20070117784A1 | 2007-05-24 | |||
| US6759038B2 | 2004-07-06 | |||
| US20060068464A1 | 2006-03-30 |
Other References:
POYNER ET AL.: "International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene- Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors", PHARMACOL REV, vol. 54, 2002, pages 233 - 246
ITTNER ET AL.: "Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 319, 2004, pages 1203 - 1209
HEROUX ET AL.: "Assembly and Signaling of CRLR and RAMP1 Complexes Assessed by BRET", BIOCHEMISTRY, vol. 46, no. 23, 2007, pages 7022 - 7033
UDAWELA ET AL.: "A Critical Role for the Short Intracellular C Terminus in Receptor Activity- Modifying Protein Function", MOL PHARMACOL, vol. 70, 15 August 2006 (2006-08-15), pages 1750 - 1760
ITTNER ET AL.: "Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 319, 2004, pages 1203 - 1209
HEROUX ET AL.: "Assembly and Signaling of CRLR and RAMP1 Complexes Assessed by BRET", BIOCHEMISTRY, vol. 46, no. 23, 2007, pages 7022 - 7033
UDAWELA ET AL.: "A Critical Role for the Short Intracellular C Terminus in Receptor Activity- Modifying Protein Function", MOL PHARMACOL, vol. 70, 15 August 2006 (2006-08-15), pages 1750 - 1760
Attorney, Agent or Firm:
MERKEL, Edwin, V. (1100 Clinton SquareRochester, NY, US)
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