Title:
METHODS FOR TREATING CANCER WITH GHRH AGONISTS
Document Type and Number:
WIPO Patent Application WO/2015/100423
Kind Code:
A3
Abstract:
Embodiments of the present disclosure are directed to methods to treat a subject having cancer. In one embodiment, a method of treating a subject with cancer may comprise administering a therapeutically effective amount of at least one GHRH agonist peptide in combination with at least one anticancer agent. In another embodiment, a method of killing cancer cells may comprise contacting the cancer cells with a composition comprising at least one GHRH agonist peptide and at least one anticancer agent. In some embodiments, the method may be in vitro or in vivo. In an additional embodiment, a method of killing cancer stem cells may comprise contacting the cancer stem cells with a composition comprising at least one GHRH agonist peptide and at least one anticancer agent.
Inventors:
SCHALLY ANDREW V (US)
JASBERENYI MIKLOS (US)
JASBERENYI MIKLOS (US)
Application Number:
PCT/US2014/072374
Publication Date:
September 17, 2015
Filing Date:
December 24, 2014
Export Citation:
Assignee:
UNIV MIAMI (US)
US OF AMERICA REPRESENTED BY THE DEPT OF VETERANS AFFAIRS (US)
US OF AMERICA REPRESENTED BY THE DEPT OF VETERANS AFFAIRS (US)
International Classes:
A61K38/00; A61K38/25; A61K38/16; C07K5/00; C07K14/60
Foreign References:
| US20060128615A1 | 2006-06-15 |
Other References:
SEITZ ET AL.: "Combination of GHRH antagonists and docetaxel shows experimental effectiveness for the treatment of triple-negative breast cancers.", ONCOL REP., vol. 30, no. 1, pages 413 - 418, ISSN: 1021-335x
JASZBERENYI ET AL.: "Potentiation of cytotoxic chemotherapy by growth hormone-releasing hormone agonists.", PROC NATL ACAD SCI USA, vol. 111, no. 2, pages 781 - 6, XP055223738, DOI: doi:10.1073/pnas.1322622111
JASZBERENYI ET AL.: "Potentiation of cytotoxic chemotherapy by growth hormone-releasing hormone agonists.", PROC NATL ACAD SCI USA, vol. 111, no. 2, pages 781 - 6, XP055223738, DOI: doi:10.1073/pnas.1322622111
Attorney, Agent or Firm:
SRINIVAS, Harish (Suite 5000500 Grant Stree, Pittsburgh Pennsylvania, US)
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