METHODS FOR TREATING DENTAL CONDITIONS USING TISSUE SCAFFOLDS

Title:

METHODS FOR TREATING DENTAL CONDITIONS USING TISSUE SCAFFOLDS

Document Type and Number:

WIPO Patent Application WO2005034789

Kind Code:

A3

Abstract:

The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fuloride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-beta surpergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.

More Like This:

WO/1993/007829	DEVICE FOR RECONSTRUCTING DAMAGED TEETH
JP4330556	Medical paste kneading injector

Inventors:

RUTHERFORD BRUCE
SOMOGYL CHRISTOPHER
WHITE CLINTON
RABINS ERIC

Application Number:

PCT/US2004/033347

Publication Date:

December 08, 2005

Filing Date:

October 08, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

DENTIGENIX INC (US)

International Classes:

A61C5/04; A61K6/00; (IPC1-7): A61C5/00; A61C17/06; A61C3/00

Foreign References:

US5885829A	1999-03-23
US4822278A	1989-04-18
US20040058442A1	2004-03-25
US5871360A	1999-02-16
US2885782A	1959-05-12
US5855562A	1999-01-05

Other References: