METHODS OF TREATING INFLAMMATION

WIPO Patent Application WO/2011/038149

A3

Disclosed herein, in some embodiments, are methods for treating an MIF-mediated disorder. In some embodiments, the method comprises administering an agent that inhibits (i) MIF binding to CXCR2 and CXCR4 and/or (ii) MIF- activation of CXCR2 and CXCR4; (iii) the ability of MIF to form a homomultimer; or a combination thereof.

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BERNHAGEN JURGEN (DE)
WEBER CHRISTIAN (DE)
VOLLRATH BENEDIKT (US)
TURNER COURT (US)
SCHULTS JOSHUA ROBERT (US)
ZERNECKE ALMA (DE)
DURON SERGIO (US)

PCT/US2010/050047

October 27, 2011

September 23, 2010

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CAROLUS THERAPEUTICS INC (US)
BERNHAGEN JURGEN (DE)
WEBER CHRISTIAN (DE)
VOLLRATH BENEDIKT (US)
TURNER COURT (US)
SCHULTS JOSHUA ROBERT (US)
ZERNECKE ALMA (DE)
DURON SERGIO (US)

C07K19/00; A61K38/18; A61P35/00; C07K7/06; C07K7/08; C07K14/435

US20040009149A1	2004-01-15
EP1724286A1	2006-11-22
US20040115193A1	2004-06-17
US20070071675A1	2007-03-29
US20050176039A1	2005-08-11

VENKATA ET AL.: "Chemically programmed antibodies: Endothelin receptor targeting CovX-bodies", BIOORGANIC AND MEDICAL CHEMISTRY LETTERS, vol. 17, 2007, pages 501 - 506, XP008154000
See also references of EP 2480579A4

HOSTETLER, Michael, J. et al. (650 Page Mill RoadPalo Alto, CA, US)

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