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Patent Searching and Data


Title:
METHODS OF TREATING PAIN AND INFLAMMATION IN NEURONAL TISSUE USING IL-31RA AND OSMRB ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2007/133816
Kind Code:
A3
Abstract:
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

Inventors:
YAO YUE (US)
BILSBOROUGH JANINE (US)
KRESJA CECILE (US)
ZUCKERMAN LINDA (US)
ROGGE MARK (US)
Application Number:
PCT/US2007/060337
Publication Date:
November 18, 2010
Filing Date:
January 10, 2007
Export Citation:
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Assignee:
ZYMOGENETICS INC (US)
YAO YUE (US)
BILSBOROUGH JANINE (US)
KRESJA CECILE (US)
ZUCKERMAN LINDA (US)
ROGGE MARK (US)
International Classes:
A61K38/17; A61K38/20; A61P17/02; A61P25/00; A61P31/12; C07K16/24; C07K16/28; A61K39/00
Domestic Patent References:
WO2002000721A22002-01-03
WO2004003140A22004-01-08
Other References:
BANDO T ET AL: "Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns", NEUROSCIENCE, NEW YORK, NY, US LNKD- DOI:10.1016/J.NEUROSCIENCE.2006.07.009, vol. 142, no. 4, 3 November 2006 (2006-11-03), pages 1263 - 1271, XP024987152, ISSN: 0306-4522, [retrieved on 20061103]
SONKOLY ET AL: "IL-31: A new link between T cells and pruritus in atopic skin inflammation", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY, INC, US LNKD- DOI:10.1016/J.JACI.2005.10.033, vol. 117, no. 2, 1 February 2006 (2006-02-01), pages 411 - 417, XP005275427, ISSN: 0091-6749
Attorney, Agent or Firm:
ADAMS, Robyn et al. (Seattle, WA, US)
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