Title:
METHODS OF TREATING SICKLE CELL DISORDER AND RELATED CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2022/240804
Kind Code:
A3
Abstract:
The present disclosure is directed to administration of native or recombinant human PRG4 (rhPRG4) as a means to treat sickle cell disease or other disorders in subjects in need of treatment thereof.
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Inventors:
XIAO LIPING (US)
HURLEY MARJA (US)
SCHMIDT TANNIN (US)
HURLEY MARJA (US)
SCHMIDT TANNIN (US)
Application Number:
PCT/US2022/028470
Publication Date:
December 29, 2022
Filing Date:
May 10, 2022
Export Citation:
Assignee:
XIAO LIPING (US)
HURLEY MARJA (US)
SCHMIDT TANNIN (US)
UNIV CONNECTICUT (US)
HURLEY MARJA (US)
SCHMIDT TANNIN (US)
UNIV CONNECTICUT (US)
International Classes:
A61K38/17
Foreign References:
| US20200215156A1 | 2020-07-09 |
Other References:
VAN BEERS E. J., NIEUWDORP M., DUITS A. J., EVERS L. M., SCHNOG J.-J. B., BIEMOND B. J.: "Sickle cell patients are characterized by a reduced glycocalyx volume", HAEMATOLOGICA, FONDAZIONE FERRATA STORTI, IT, vol. 93, no. 2, 1 February 2008 (2008-02-01), IT , pages 307 - 308, XP093020824, ISSN: 0390-6078, DOI: 10.3324/haematol.12027
HEMPEL CASPER; PASINI ERICA M.; KURTZHALS JøRGEN A.L.: "Endothelial Glycocalyx: Shedding Light on Malaria Pathogenesis", TRENDS IN MOLECULAR MEDICINE, ELSEVIER CURRENT TRENDS, GB, vol. 22, no. 6, 5 May 2016 (2016-05-05), GB , pages 453 - 457, XP029555045, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2016.04.004
HEMPEL CASPER; PASINI ERICA M.; KURTZHALS JøRGEN A.L.: "Endothelial Glycocalyx: Shedding Light on Malaria Pathogenesis", TRENDS IN MOLECULAR MEDICINE, ELSEVIER CURRENT TRENDS, GB, vol. 22, no. 6, 5 May 2016 (2016-05-05), GB , pages 453 - 457, XP029555045, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2016.04.004
Attorney, Agent or Firm:
MUELLER, Lisa (US)
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