Title:
METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002058690
Kind Code:
A3
Abstract:
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.
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Inventors:
ARRHENIUS THOMAS (US)
CHEN MI (US)
CHENG JIE FEI (US)
HARAMURA MASAYUKI (US)
HUANG YUJIN (US)
NADZAN ALEX (US)
TITH SOVOUTHY (US)
WALLACE DAVID (US)
ZHANG LIN (US)
BROWN STEVE (US)
HARMON CHARLES (US)
CHEN MI (US)
CHENG JIE FEI (US)
HARAMURA MASAYUKI (US)
HUANG YUJIN (US)
NADZAN ALEX (US)
TITH SOVOUTHY (US)
WALLACE DAVID (US)
ZHANG LIN (US)
BROWN STEVE (US)
HARMON CHARLES (US)
Application Number:
PCT/US2002/001814
Publication Date:
April 24, 2003
Filing Date:
January 22, 2002
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
ARRHENIUS THOMAS (US)
CHEN MI (US)
CHENG JIE FEI (US)
HARAMURA MASAYUKI (US)
HUANG YUJIN (US)
NADZAN ALEX (US)
TITH SOVOUTHY (US)
WALLACE DAVID (US)
ZHANG LIN (US)
BROWN STEVE (US)
HARMON CHARLES (US)
ARRHENIUS THOMAS (US)
CHEN MI (US)
CHENG JIE FEI (US)
HARAMURA MASAYUKI (US)
HUANG YUJIN (US)
NADZAN ALEX (US)
TITH SOVOUTHY (US)
WALLACE DAVID (US)
ZHANG LIN (US)
BROWN STEVE (US)
HARMON CHARLES (US)
International Classes:
C07D295/18; A61K31/16; A61K31/165; A61K31/166; A61K31/167; A61K31/17; A61K31/175; A61K31/18; A61K31/195; A61K31/197; A61K31/198; A61K31/21; A61K31/215; A61K31/216; A61K31/22; A61K31/221; A61K31/223; A61K31/27; A61K31/275; A61K31/277; A61K31/341; A61K31/381; A61K31/40; A61K31/404; A61K31/41; A61K31/415; A61K31/416; A61K31/4164; A61K31/4172; A61K31/4178; A61K31/4188; A61K31/4196; A61K31/42; A61K31/421; A61K31/4245; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4439; A61K31/444; A61K31/445; A61K31/4453; A61K31/451; A61K31/455; A61K31/495; A61K31/498; A61K31/5375; A61K31/5377; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C33/46; C07C33/48; C07C215/24; C07C233/22; C07C257/22; C07C279/18; C07C307/10; C07C323/14; C07C335/18; C07D209/42; C07D211/14; C07D211/22; C07D213/40; C07D213/56; C07D213/70; C07D213/75; C07D213/81; C07D213/82; C07D231/06; C07D231/12; C07D231/14; C07D231/38; C07D231/40; C07D233/54; C07D233/64; C07D233/84; C07D233/90; C07D239/42; C07D241/24; C07D257/04; C07D261/04; C07D261/08; C07D261/14; C07D261/18; C07D263/34; C07D271/06; C07D277/46; C07D277/48; C07D277/52; C07D285/135; C07D295/13; C07D295/194; C07D295/21; C07D295/215; C07D295/22; C07D295/28; C07D307/46; C07D307/52; C07D307/68; C07D333/24; C07D401/04; C07D401/12; C07D403/12; C07D405/12; C07D409/04; C07D413/06; C07D413/12; C07D417/12; C07D417/14; C07D487/08; C07D498/08; C07F9/24; C07F9/40; C07F9/6539; C07D285/12; (IPC1-7): A61K31/16; A61K31/41; A61K31/415; A61K31/4164; A61K31/44; A61K31/42; A61K31/5375; A61P3/04; A61P3/10; A61P9/10; A61P35/00; C07D233/64
Domestic Patent References:
| WO2001003705A1 | 2001-01-18 | |||
| WO2000054759A2 | 2000-09-21 | |||
| WO2002058698A2 | 2002-08-01 | |||
| WO2002064136A2 | 2002-08-22 |
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