Title:
METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS
Document Type and Number:
WIPO Patent Application WO/2017/123568
Kind Code:
A3
Abstract:
The invention features methods of treating disorders related to increased levels of myeloid derived suppressor cells such as cancer or infections. The disclosure also provides methods of treating cancer including combinations of LXRβ agonists and immunotherapies such as PD1 inhibitors, PDL1 inhibitors, and adoptive T-cell transfer therapy.
Inventors:
TAVAZOIE SOHAIL (US)
TAVAZOIE MASOUD (US)
TAVAZOIE MASOUD (US)
Application Number:
PCT/US2017/012906
Publication Date:
August 17, 2017
Filing Date:
January 11, 2017
Export Citation:
Assignee:
UNIV ROCKEFELLER (US)
International Classes:
A61K31/195; A61K31/197; A61K31/513; A61K31/7068; A61K45/06; A61K48/00; C07K16/18
Domestic Patent References:
| WO2011115892A1 | 2011-09-22 |
Foreign References:
| US20150073053A1 | 2015-03-12 | |||
| US20170066791A1 | 2017-03-09 | |||
| US20170119807A1 | 2017-05-04 |
Other References:
OSTRAND-ROSENBERG, S ET AL.: "Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer", THE JOURNAL OF IMMUNOLOGY, vol. 182, no. 8, 15 April 2009 (2009-04-15), pages 499 - 4506, XP002588069
Attorney, Agent or Firm:
NORTON, Gerard, P. et al. (US)
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