Title:
METHODS FOR TREATMENT OF NON-ALCOHOLIC HEPATIC STEATOSIS AND HEPATIC STEATOHEPATITIS USING ILEAL BRAKE HORMONE RELEASING SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2017/203367
Kind Code:
A3
Abstract:
The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Hon Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of.metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and/or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.
Inventors:
SCHENTAG JEROME (US)
FAYAD JOSEPH M (US)
FAYAD JOSEPH M (US)
Application Number:
PCT/IB2017/000780
Publication Date:
March 01, 2018
Filing Date:
May 22, 2017
Export Citation:
Assignee:
VOLANT HOLDINGS GMBH (CH)
International Classes:
G01N33/68
Domestic Patent References:
| WO2016011335A1 | 2016-01-21 | |||
| WO2012118712A2 | 2012-09-07 |
Foreign References:
| US20140294951A1 | 2014-10-02 |
Other References:
P. J. MALJAARS ET AL: "An ileal brake-through?", THE AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 92, no. 3, 4 August 2010 (2010-08-04), US, pages 467 - 468, XP055418329, ISSN: 0002-9165, DOI: 10.3945/ajcn.2010.30180
THER ADV: "Therapeutic Advances in Gastroenterology Review", 1 January 2012 (2012-01-01), pages 199 - 207, XP055418336, Retrieved from the Internet
THER ADV: "Therapeutic Advances in Gastroenterology Review", 1 January 2012 (2012-01-01), pages 199 - 207, XP055418336, Retrieved from the Internet
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