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Title:
METHODS OF USE OF THROMBIN RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2005046688
Kind Code:
A3
Abstract:
A method of treating a therapeutic condition comprising administering to a mammal in need of such treatment an effective amount of at least one compound of the formulas (I) and (II) or a pharmaceutically acceptable isomer, salt, solvate or co-crystal form thereof, wherein the substituents are as defined in the specification, wherein said therapeutic condition is a cardiovascular or circulatory disease or condition, an inflammatory disease or condition, a respiratory tract or disease or condition, cancer, acute renal failure, astrogliosis, a fibrotic disorder of the liver, kidney, lung or intestinal tract, Alzheimer's disease, diabetes, diabetic neuropathy, rheumatoid arthritis, neurodegenerative disease, neurotoxic disease, systemic lupus erythematosus, multiple sclerosis, osteoporosis, glaucoma, macular degeneration, psoriasis, radiation fibrosis, endothelial dysfunction, a wound or a spinal cord injury, or a symptom or result thereof. Combination therapy with other therapeutically effective agents is also disclosed.

Inventors:
CHACKALAMANNIL SAMUEL (US)
CLASBY MARTIN C (US)
GREENLEE WILLIAM J (US)
WANG YUGUANG (US)
XIA YAN (US)
VELTRI ENRICO P (US)
CHELLIAH MARIAPPAN V (US)
WU WENXUE (US)
GRAZIANO MICHAEL P (US)
KOSOGLOU TEDDY (US)
CHINTALA MADHU (US)
Application Number:
US2004037519W
Publication Date:
September 29, 2005
Filing Date:
November 09, 2004
Export Citation:
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Assignee:
SCHERING CORPORATION
CHACKALAMANNIL, SAMUEL
CLASBY, MARTIN, C.
GREENLEE, WILLIAM, J.
WANG, YUGUANG
XIA, YAN
VELTRI, ENRICO, P.
CHELLIAH, MARIAPPAN, V.
WU, WENXUE
GRAZIANO, MICHAEL, P.
KOSOGLOU, TEDDY
CHINTALA, MADHU
International Classes:
A61K31/343; A61K31/4525; C07D405/06; C07D405/14; C07D413/14; C07D417/14; C07D521/00; (IPC1-7): A61K31/4525; A61K31/343; A61P9/00; A61P29/00; A61P11/00; A61P35/00; A61P25/28; A61P13/12
Domestic Patent References:
WO2001096330A22001-12-20
WO2003089428A12003-10-30
Foreign References:
US20040152736A12004-08-05
Other References:
DATABASE WPI Section Ch Week 200416, Derwent World Patents Index; Class B02, AN 2004-159343, XP002323767
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