METHODS FOR USING ADAMTS-12, AN INTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS

Title:

METHODS FOR USING ADAMTS-12, AN INTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS

Document Type and Number:

WIPO Patent Application WO2003103478

Kind Code:

A3

Abstract:

The present invention relates to methods for using a human A Disintegrin And Metalloprotease containing ThromboSpondin repeats (ADAM-TS). The invention also relates to methods for using polynucleotides encoding the metalloprotease. The invention relates to methods using the ADAM-TS polypeptides and polynucleotides as a target for diagnosis and treatment in metalloprotease-mediated or -related disorders. The invention further relates to drug-screening method using the ADAM-TS polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADAM-TS polypeptides and polynucleotides. The invention further relates to antagonists identified by drug screening methods with the ADAM-TS polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from a ADAM-TS associated disorder.

Inventors:

JACKSON PAUL DAVID (US)
TING ANTHONY EUGENE (US)
FABER PIETER W (US)

Application Number:

PCT/US2003/018125

Publication Date:

March 24, 2005

Filing Date:

June 06, 2003

Export Citation:

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Assignee:

ATHERSYS INC (US)
JACKSON PAUL DAVID (US)
TING ANTHONY EUGENE (US)
FABER PIETER W (US)

International Classes:

A61K38/00; A61K39/395; A61K45/00; G01N33/53; A61P9/00; A61P9/10; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07H21/04; C12N9/64; C12N15/00; C12N15/09; C12Q1/00; C12Q1/02; C12Q1/37; C12Q1/68; G01N33/50; G01N33/573; G01N33/574; A61B; (IPC1-7): C12N15/00; C12N15/09; C12Q1/68; C07H21/04

Foreign References:

US20010049106A1	2001-12-06
US20020110894A1	2002-08-15

Other References:

CAL, ET AL.: "Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 21, 25 May 2001 (2001-05-25), pages 17932 - 17940, XP002308159

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