Title:
METHODS OF USING ALPHA 1B-ADRENERGIC RECEPTORS
Document Type and Number:
WIPO Patent Application WO2003081259
Kind Code:
A3
Abstract:
The present invention relates generally to alpha-1b-adrenergic receptors and to methods for use of alpha 1 b-ARs. In particular, the invention relates to the use of such methods for the identification of modulators of alpha 1 b-adrenergic receptor activity.
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Inventors:
COTECCHIA SUSANNA (CH)
Application Number:
PCT/IB2003/001643
Publication Date:
May 21, 2004
Filing Date:
March 25, 2003
Export Citation:
Assignee:
UNIV LAUSANNE (CH)
COTECCHIA SUSANNA (CH)
COTECCHIA SUSANNA (CH)
International Classes:
G01N33/50; G01N33/94; (IPC1-7): G01N33/94; G01N33/74; G01N33/50; C07K14/705; A01K67/027
Domestic Patent References:
| WO2001084919A1 | 2001-11-15 | |||
| WO2000049416A2 | 2000-08-24 |
Foreign References:
| US5861309A | 1999-01-19 |
Other References:
CAVALLI ANTONELLA ET AL: "Decreased blood pressure response in mice deficient of the alpha-1b-adrenergic receptor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 94, no. 21, 1997, 1997, pages 11589 - 11594, XP002259215, ISSN: 0027-8424
LATTION ANNE-LAURE ET AL: "Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha-1beta-adrenergic receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 36, 1994, pages 22887 - 22893, XP002270305, ISSN: 0021-9258
HEIN PETER ET AL: "A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 363, no. 1, January 2001 (2001-01-01), pages 34 - 39, XP002259218, ISSN: 0028-1298
DROUIN CANDICE ET AL: "alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates", JOURNAL OF NEUROSCIENCE, vol. 22, no. 7, 1 April 2002 (2002-04-01), pages 2873 - 2884, XP002259216, ISSN: 0270-6474
KNAUBER J ET AL: "DECREASED EXPLORATORY ACTIVITY AND IMPAIRED PASSIVE AVOIDANCE BEHAVIOUR IN MICE DEFICIENT FOR THE ALPHA1B-ADRENOCEPTOR", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. 10, no. 6, December 2000 (2000-12-01), pages 423 - 427, XP001155755, ISSN: 0924-977X
PIASCIK MICHAEL T ET AL: "alpha1-Adrenergic receptors: New insights and directions", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 298, no. 2, August 2001 (2001-08-01), pages 403 - 410, XP002259217, ISSN: 0022-3565
SPRENG MATTHIEU ET AL: "A behavioral study of alpha-1b adrenergic receptor knockout mice: Increased reaction to novelty and selectively reduced learning capacities", NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 75, no. 2, March 2001 (2001-03-01), pages 214 - 229, XP002259219, ISSN: 1074-7427
DROUIN C ET AL: "CRITICAL ROLE OF ALPHA1-ADRENERGIC RECEPTORS IN ACUTE AND SENSITIZED LOCOMOTER EFFECTS OF D-AMPHETAMINE, COCAINE, AND GBR 12783: INFLUENCE OF PREEXPOSURE CONDITIONS AND PHARMACOLOGICAL CHARACTERISTICS", SYNAPSE, WILEY AND SONS, CHICHESTER, GB, vol. 43, no. 1, January 2002 (2002-01-01), pages 51 - 61, XP009023730, ISSN: 0887-4476
LATTION ANNE-LAURE ET AL: "Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha-1beta-adrenergic receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 36, 1994, pages 22887 - 22893, XP002270305, ISSN: 0021-9258
HEIN PETER ET AL: "A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 363, no. 1, January 2001 (2001-01-01), pages 34 - 39, XP002259218, ISSN: 0028-1298
DROUIN CANDICE ET AL: "alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates", JOURNAL OF NEUROSCIENCE, vol. 22, no. 7, 1 April 2002 (2002-04-01), pages 2873 - 2884, XP002259216, ISSN: 0270-6474
KNAUBER J ET AL: "DECREASED EXPLORATORY ACTIVITY AND IMPAIRED PASSIVE AVOIDANCE BEHAVIOUR IN MICE DEFICIENT FOR THE ALPHA1B-ADRENOCEPTOR", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. 10, no. 6, December 2000 (2000-12-01), pages 423 - 427, XP001155755, ISSN: 0924-977X
PIASCIK MICHAEL T ET AL: "alpha1-Adrenergic receptors: New insights and directions", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 298, no. 2, August 2001 (2001-08-01), pages 403 - 410, XP002259217, ISSN: 0022-3565
SPRENG MATTHIEU ET AL: "A behavioral study of alpha-1b adrenergic receptor knockout mice: Increased reaction to novelty and selectively reduced learning capacities", NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 75, no. 2, March 2001 (2001-03-01), pages 214 - 229, XP002259219, ISSN: 1074-7427
DROUIN C ET AL: "CRITICAL ROLE OF ALPHA1-ADRENERGIC RECEPTORS IN ACUTE AND SENSITIZED LOCOMOTER EFFECTS OF D-AMPHETAMINE, COCAINE, AND GBR 12783: INFLUENCE OF PREEXPOSURE CONDITIONS AND PHARMACOLOGICAL CHARACTERISTICS", SYNAPSE, WILEY AND SONS, CHICHESTER, GB, vol. 43, no. 1, January 2002 (2002-01-01), pages 51 - 61, XP009023730, ISSN: 0887-4476
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