Title:
METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF ASBESTOS-RELATED DISEASES AND DISORDERS
Document Type and Number:
WIPO Patent Application WO2005046592
Kind Code:
A3
Abstract:
Methods of treating, preventing and managing an asbestos-related disease or disorder are disclosed. Specific embodiments encompass the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or chemotherapy, surgery, or radiation therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.
Inventors:
ZELDIS JEROME B (US)
Application Number:
PCT/US2004/037082
Publication Date:
December 15, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
CELGENE CORP (US)
ZELDIS JEROME B (US)
ZELDIS JEROME B (US)
International Classes:
A61K31/28; A61K31/335; A61K31/40; A61K31/44; A61K31/519; A61K31/70; A61K31/704; A61K31/7048; A61K38/19; A61K38/20; A61K; (IPC1-7): A61K31/28; A61K31/40; A61K31/44; A61K31/70; A61K31/335
Other References:
DATABASE CAPLUS [online] EGGENWEILER H ET AL: "Type 4 phosphodiesterase inhibitors and therapeutic uses thereof.", XP002994315, accession no. STN (COLUMBUS OH, USA) Database accession no. (138:348761)
DATABASE MEDLINE [online] VOGELZANG N. ET AL: "Malignant mesothelioma", XP002994316, accession no. STN (Columbus, OH, USA) Database accession no. (84106225)
DATABASE MEDLINE [online] HO L. ET AL: "Malignant pleural mesothelioma", XP002994317, accession no. STN (Columbus, oh, USA) Database accession no. (2001257749)
DATABASE MEDLINE [online] VOGELZANG N. ET AL: "Malignant mesothelioma", XP002994316, accession no. STN (Columbus, OH, USA) Database accession no. (84106225)
DATABASE MEDLINE [online] HO L. ET AL: "Malignant pleural mesothelioma", XP002994317, accession no. STN (Columbus, oh, USA) Database accession no. (2001257749)
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