Title:
METHODS OF USING MICRORNA 195 IN PROVIDING NEUROPROTECTION
Document Type and Number:
WIPO Patent Application WO/2013/067531
Kind Code:
A3
Abstract:
The invention relates to a method for providing neuroprotection comprising administering to a subject an effective amount of a miRNA or a variant thereof. By providing neuroprotection,, stroke or ischemic stroke can be prevented and/or treated.
Inventors:
JUO SUH-HANG H
WANG YUNG-SONG
CHENG HSIN-YUN
WANG YUNG-SONG
CHENG HSIN-YUN
Application Number:
PCT/US2012/063604
Publication Date:
July 03, 2014
Filing Date:
November 05, 2012
Export Citation:
Assignee:
DCB USA LLC (US)
UNIV KAOHSIUNG MEDICAL
JUO SUH-HANG H
WANG YUNG-SONG
CHENG HSIN-YUN
UNIV KAOHSIUNG MEDICAL
JUO SUH-HANG H
WANG YUNG-SONG
CHENG HSIN-YUN
International Classes:
C12N15/11
Foreign References:
| US20050261218A1 | 2005-11-24 | |||
| US20100317713A1 | 2010-12-16 |
Other References:
YIN ET AL.: "Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia- induced cerebral vascular endothelial injury.", J NEUROSCI, vol. 30, no. 18, 5 May 2010 (2010-05-05), pages 6398 - 6408, XP002637213
LIU ET AL.: "microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells.", BIOCHEM BIOPHYS RES COMMUN, vol. 400, no. 2, 17 September 2010 (2010-09-17), pages 236 - 240, XP027288465
LEE ET AL.: "MicroRNAs induced during ischemic preconditioning.", STROKE, vol. 41, no. 8, August 2010 (2010-08-01), pages 1646 - 1651, XP055149269
MADATHIL ET AL.: "MicroRNAs in CNS injury: potential roles and therapeutic implications.", BIOESSAYS, vol. 3, no. 1, January 2011 (2011-01-01), pages 21 - 26, XP055149272, Retrieved from the Internet
YIN ET AL.: "miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia.", NEUROBIOL DIS, vol. 38, no. 1, April 2010 (2010-04-01), pages 17 - 26, XP026935086, Retrieved from the Internet
See also references of EP 2773381A4
LIU ET AL.: "microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells.", BIOCHEM BIOPHYS RES COMMUN, vol. 400, no. 2, 17 September 2010 (2010-09-17), pages 236 - 240, XP027288465
LEE ET AL.: "MicroRNAs induced during ischemic preconditioning.", STROKE, vol. 41, no. 8, August 2010 (2010-08-01), pages 1646 - 1651, XP055149269
MADATHIL ET AL.: "MicroRNAs in CNS injury: potential roles and therapeutic implications.", BIOESSAYS, vol. 3, no. 1, January 2011 (2011-01-01), pages 21 - 26, XP055149272, Retrieved from the Internet
YIN ET AL.: "miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia.", NEUROBIOL DIS, vol. 38, no. 1, April 2010 (2010-04-01), pages 17 - 26, XP026935086, Retrieved from the Internet
See also references of EP 2773381A4
Attorney, Agent or Firm:
KING, Anthony (P.C.1100 Quail Street,Suite 20, Newport Beach CA, US)
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