Title:
METHODS FOR USING MODULATORS OF PROLINE-RICH TYROSINE KINASE 2
Document Type and Number:
WIPO Patent Application WO2005002573
Kind Code:
A3
Abstract:
The present invention relates to methods for preventing cell death in a subject and their application in the treatment of neurodegenerative diseases and conditions, such as Alzheimer's disease, stroke, Parkinson's disease etc. A method for preventing cell death comprises reducing or inhibiting Pyk2 activity.
Inventors:
GRISWOLD-PRENNER IRENE (US)
POWELL KYLE (US)
POWELL KYLE (US)
Application Number:
PCT/US2004/017713
Publication Date:
June 30, 2005
Filing Date:
June 04, 2004
Export Citation:
Assignee:
ELAN PHARM INC (US)
GRISWOLD-PRENNER IRENE (US)
POWELL KYLE (US)
GRISWOLD-PRENNER IRENE (US)
POWELL KYLE (US)
International Classes:
A61K31/00; A61K31/275; A61K31/277; A61K31/41; A61K31/47; A61K31/517; A61K48/00; C12N9/12; C12N15/11; (IPC1-7): A61K31/277; A61K31/47; A61P25/28; C12N15/11
Domestic Patent References:
| WO2000049144A2 | 2000-08-24 | |||
| WO2000040971A1 | 2000-07-13 |
Foreign References:
| US20020048782A1 | 2002-04-25 |
Other References:
FUORTES MICHELE ET AL: "Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF", JOURNAL OF CLINICAL INVESTIGATION, vol. 104, no. 3, August 1999 (1999-08-01), pages 327 - 335, XP002314638, ISSN: 0021-9738
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